Evaluation of Effects of Topical Melatonin Application on Osseointegration of Dental Implant: An Experimental Study

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dc.contributor.authorDundar, Serkan
dc.contributor.authorYaman, Ferhan
dc.contributor.authorSaybak, Arif
dc.contributor.authorOzupek, M. Fatih
dc.contributor.authorToy, Vesile Elif
dc.contributor.authorGul, Mehmet
dc.contributor.authorOzercan, I. Hanifi
dc.date.accessioned2024-04-24T17:18:05Z
dc.date.available2024-04-24T17:18:05Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe aim of the present study was to evaluate the effect of local melatonin application during surgery on bone implant connection (BIC) in rabbit tibiae. Six 0.8- to 1-year-old male New Zealand rabbits were divided into 3 groups: (1) a control group (CG) in which rabbits were not treated with additive materials and only implant integration was executed; (2) a melatonin dose 1 (MLT D-1) group in which rabbits were treated with 1.2 mg of melatonin locally before implant placement into the rabbits' tibiae; and (3) a melatonin dose 2 (MLT D-2) group in which rabbits were treated with 3 mg melatonin locally before implant placement into the rabbits' tibiae. Four weeks after the procedure, the rabbits were euthanized; their tibiae were dissected from muscles and soft tissues, fixed with formaldehyde, and later embedded in methacrylate. Histologic and histomorphometric analyses were then performed under light microscopy. Following this, BIC was detected histomorphometrically, and P<.05 was considered statistically significant. Results showed that the highest BIC percentage was detected in MLT D-2, with a mean value of 39.46% +/- 0.78, as compared with a mean value of 33.89% +/- 0.92 in group MLT D-1 and 27.42% +/- 0.89 in CG. Similarly, the mean BIC percentage of the MLT D-2 group was the highest among the three, with the mean BIC percentage of the MLT D-1 still registering as higher than CG. Within the limitations of this rabbit study, it appears that local melatonin application during implant surgery may improve BIC.en_US
dc.identifier.doi10.1563/aaid-joi-D-16-00048
dc.identifier.endpage389en_US
dc.identifier.issn0160-6972
dc.identifier.issn1548-1336
dc.identifier.issue5en_US
dc.identifier.pmid27327091
dc.identifier.scopus2-s2.0-84992184213
dc.identifier.scopusqualityQ2
dc.identifier.startpage386en_US
dc.identifier.urihttps://doi.org/10.1563/aaid-joi-D-16-00048
dc.identifier.urihttps://hdl.handle.net/11468/18597
dc.identifier.volume42en_US
dc.identifier.wosWOS:000385087800002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAllen Press Incen_US
dc.relation.ispartofJournal of Oral Implantology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBone Implant Connectionen_US
dc.subjectImplanten_US
dc.subjectLocal Melatoninen_US
dc.subjectRabbiten_US
dc.subjectBoneen_US
dc.titleEvaluation of Effects of Topical Melatonin Application on Osseointegration of Dental Implant: An Experimental Studyen_US
dc.titleEvaluation of Effects of Topical Melatonin Application on Osseointegration of Dental Implant: An Experimental Study
dc.typeArticleen_US

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