Increased oxidative stress is associated with thiol/disulphide homeostasis in clomiphene citrate resistant polycystic ovary syndrome

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dc.contributor.authorEge, Serhat
dc.contributor.authorBademkiran, Muhammet Hanifi
dc.contributor.authorPeker, Nurullah
dc.contributor.authorOzgun, Zinet
dc.contributor.authorBagli, Ihsan
dc.contributor.authorErdem, Selami
dc.contributor.authorErel, Ozcan
dc.date.accessioned2024-04-24T16:24:27Z
dc.date.available2024-04-24T16:24:27Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe purpose of this study was to evaluate the relation CC resistant PCOS and the thiol/disulphide homeostasis, used as a marker of OS, by measuring that exchange using a novel technique. Sixty women patients admitted to the infertility clinic were evaluated. The patients were divided into two groups. Group 1 comprised 30 infertile PCOS patients with CC resistance; Group 2 was the control group comprising 30 infertile PCOS patients with CC sensitivity. Serum total thiol (p = .024), native thiol (p = .0052), disulphide (p = .003), index 1 (p = .001), index 2 (p = .001) and index 3 (p = .001), HOMA-IR (p < .001) and free testosterone (p < .001) were statistically significant. The independent variables BMI and age effects were adjusted according to the logistic regression method with groups. Significant differences were observed between the two groups in the levels of native thiol (p* = .0042), total thiol (p* = .024), disulphide (p* = .0003), index 1 (p* = .0001) index 2 (p*= .0001), index 3 (p* = .0001), HOMA-IR (p* = .0044), insulin (p*= .032) and free testosterone (p* = .0001) values. The thiol/disulphide homeostasis viewed in favour of OS. Like a reflection of OS in the follicular endocrine microenvironment may be linked with increased thiol/disulphide homeostasis, free testosterone, insulin and HOMA-IR levels.Impact statement What is already known about this subject?In previous studies, thiol/disulphide homeostasis was compared between PCOS and control groups. In this study, serum thiol/disulphide homeostasis was measured in infertile PCOS patients resistant to CC for the first time. What do the results of this study add?Disulphide concentrations were significantly higher in patients with CC resistant patients thanthe control group. This shows us that more OS occurs in the CC-resistant group. What are the implications of these findings for clinical practice and further research?Thiol/disulphide homeostasis will be a guide for PCOS management in patients with CC-resistant PCOS.en_US
dc.identifier.doi10.1080/01443615.2020.1786033
dc.identifier.endpage470en_US
dc.identifier.issn0144-3615
dc.identifier.issn1364-6893
dc.identifier.issue3en_US
dc.identifier.pmid32586152
dc.identifier.scopus2-s2.0-85087154981
dc.identifier.scopusqualityQ3
dc.identifier.startpage467en_US
dc.identifier.urihttps://doi.org/10.1080/01443615.2020.1786033
dc.identifier.urihttps://hdl.handle.net/11468/16721
dc.identifier.volume41en_US
dc.identifier.wosWOS:000548675100001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Obstetrics and Gynaecology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThiolen_US
dc.subjectDisulphide Homeostasisen_US
dc.subjectClomiphene Citrate Resistanten_US
dc.subjectOxidative Stressen_US
dc.subjectPolycystic Ovary Syndromeen_US
dc.titleIncreased oxidative stress is associated with thiol/disulphide homeostasis in clomiphene citrate resistant polycystic ovary syndromeen_US
dc.titleIncreased oxidative stress is associated with thiol/disulphide homeostasis in clomiphene citrate resistant polycystic ovary syndrome
dc.typeArticleen_US

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