Dilated ureter for esophageal substitution: A preliminary experimental study in the rat

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dc.contributor.authorUygun, Ibrahim
dc.contributor.authorOtcu, Selcuk
dc.contributor.authorOzekinci, Selver
dc.contributor.authorOkur, Mehmet Hanifi
dc.contributor.authorArslan, Mehmet Serif
dc.contributor.authorAydogdu, Bahattin
dc.date.accessioned2024-04-24T16:11:05Z
dc.date.available2024-04-24T16:11:05Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Esophageal replacement using digestive organs such as the colon, stomach, or jejunum has been used to treat long-gap esophageal atresia and caustic esophageal strictures. Nevertheless, it presents a major challenge. Here, we report a preliminary experimental study that examined the use of a free dilated ureter as an option for esophageal substitution in a transplantation rat model. Methods: Ten 28-week-old male donor rats underwent distal ureteral ligation for 4 weeks, and the total dilated ureters were recovered. In each of the ten recipient 20-week-old male rats, a ureter was transplanted through the mediastinum into the esophageal bed, without vascular anastomosis. All rats received cyclosporine and cotrimoxazole for 10 days. On postoperative day 10, the rats were sacrificed, and the transplanted ureters were evaluated macroscopically and histopathologically. Results: All procedures were achieved. In the early postoperative period, three transplanted rats died. Upon macroscopic evaluation, no evidence of complications was observed, and all transplanted ureters exhibited apparently good firm tissue. Histopathological examination showed a viable ureteral structure with good vascularity, low inflammation, and regenerated epithelium in all rats. Conclusion: As an option for esophageal substitution, heterotopic ureteral transplantation can be performed directly into the mediastinal location of the esophagus, without vascular anastomosis in a rat model. In the future, free dilated ureters might be useful for esophageal grafting or patching in humans; however, this procedure must be validated in additional large animal models before being attempted in humans. (C) 2013 Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.clinre.2013.07.009
dc.identifier.endpage98en_US
dc.identifier.issn2210-7401
dc.identifier.issn2210-741X
dc.identifier.issue1en_US
dc.identifier.pmid24011824
dc.identifier.scopus2-s2.0-84893978482
dc.identifier.scopusqualityQ2
dc.identifier.startpage92en_US
dc.identifier.urihttps://doi.org/10.1016/j.clinre.2013.07.009
dc.identifier.urihttps://hdl.handle.net/11468/15257
dc.identifier.volume38en_US
dc.identifier.wosWOS:000331221100023
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Massonen_US
dc.relation.ispartofClinics and Research in Hepatology and Gastroenterology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleDilated ureter for esophageal substitution: A preliminary experimental study in the raten_US
dc.titleDilated ureter for esophageal substitution: A preliminary experimental study in the rat
dc.typeArticleen_US

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