Effects of whole blood, crystalloid, and colloid resuscitation of hemorrhagic shock on renal damage in rats

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dc.contributor.authorÖnen, A
dc.contributor.authorÇigdem, MK
dc.contributor.authorDeveci, E
dc.contributor.authorKaya, S
dc.contributor.authorTurhanoglu, S
dc.contributor.authorYaldiz, M
dc.date.accessioned2024-04-24T16:18:40Z
dc.date.available2024-04-24T16:18:40Z
dc.date.issued2003
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: The aim of this study was to determine the effects of whole blood, crystalloid, and colloid treatment on histopathologic damage of kidney induced by hemorrhagic shock in rats. Methods: Fifty-six male Sprague Dawley rats were divided into 8 groups. The carotid artery was cannulated, and systolic arterial pressure (SAP), diastolic arterial pressure (DAP), heart rate (HR), and rectal temperature (RT) were observed during the procedure. The jugular vein also was cannulated, and the SAP was decreased by aspiration of 75% of blood through the jugular vein in the control (non resuscitated) and study (resuscitated) groups, whereas blood was not diminished in the sham group. The hemorrhagic shock was permitted to last 45 minutes; then, the study group rats were resuscitated with heparinized shed autologous whole blood (WB), normal saline (NS), Lactated Ringer's solution (LR), hydroxyethyl starch 6% (HES6), hydroxyethyl starch 10% (HES10), or dextran 40 (D40). Histopathologic evaluation was performed under light and electron microscope. Results: The RT, SAP, and DAP decreased, and HR increased significantly in the control and study groups during the shock period compared with those of sham group. After volume resuscitation, these parameters changed to preshock levels. Electron and light microscopic examinations of kidneys showed severe proximal tubular degeneration with moderate glomerular damage in the control group; moderate proximal tubular degeneration with mild glomerular damage in the NS, LR, HES6, and HES10 groups; and mild proximal tubular degeneration with no evidence of glomerular damage in the WB and D-40 groups. Conclusions: The characteristic ultrastructural features of hemorrhagic shock appear to be severe tubular degeneration and mild to moderate changes in glomeruli. Resuscitation of hemorrhagic shock with whole blood or dextran 40 solution appears to be most favorable therapy in preventing ultrastructural renal damage in rats.en_US
dc.identifier.doi10.1016/S0022-3468(03)00572-4
dc.identifier.endpage1649en_US
dc.identifier.issn0022-3468
dc.identifier.issn1531-5037
dc.identifier.issue11en_US
dc.identifier.pmid14614716
dc.identifier.scopus2-s2.0-0242524422
dc.identifier.scopusqualityQ1
dc.identifier.startpage1642en_US
dc.identifier.urihttps://doi.org/10.1016/S0022-3468(03)00572-4
dc.identifier.urihttps://hdl.handle.net/11468/16225
dc.identifier.volume38en_US
dc.identifier.wosWOS:000186565200016
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal of Pediatric Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHemorrhagic Shocken_US
dc.subjectRenal Failureen_US
dc.subjectRestoration Of Renal Damageen_US
dc.subjectWhole Blooden_US
dc.subjectCrystalloidsen_US
dc.subjectColloidsen_US
dc.subjectRatsen_US
dc.titleEffects of whole blood, crystalloid, and colloid resuscitation of hemorrhagic shock on renal damage in ratsen_US
dc.titleEffects of whole blood, crystalloid, and colloid resuscitation of hemorrhagic shock on renal damage in rats
dc.typeArticleen_US

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