Is hyperprolactinemia associated with insulin resistance in non-obese patients with polycystic ovary syndrome?

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dc.contributor.authorBahceci, M
dc.contributor.authorTuzcu, A
dc.contributor.authorBahceci, S
dc.contributor.authorTuzcu, S
dc.date.accessioned2024-04-24T15:59:41Z
dc.date.available2024-04-24T15:59:41Z
dc.date.issued2003
dc.departmentDicle Üniversitesien_US
dc.description.abstractInsulin resistance is common in polycystic ovary syndrome (PCOS). Moderate elevations in serum PRL concentration may contribute to insulin resistance in PCOS. The aim of this study was to determine PRL on development of insulin resistance in non-obese hyperprolactinemic patients with PCOS. Ninety-eight non-obese subjects with PCOS and 100 non-obese healthy control were accepted in the study. Serum glucose, lipids, androgens, free androgen index (FAI), gonadotropins, fat mass and percentage, SHBG, and insulin levels were measured. Homeostasis model assessment (HOMA) was used as index of pancreatic beta-cell function and tissue insulin sensitivity. Independent t-test was used in comparison of results. In patients with PCOS, FAI and mean HOMA-(%B) level were higher than in the control group (p<0.0001), whereas mean HOMA-(%S) in subjects with PCOS was lower than in the control group (p<0.0001). Patients with PCOS were divided into subgroups according to their serum prolactin level (<24 or greater than or equal to24 ng/ml). Although FAI was not different, mean insulin and HOMA-(%B) levels in hyperprolactinemic patients were higher than in normoprolactinemic subjects (p<0.001). HOMA-(%S) in hyperprolactinemic patients with PCOS was lower than in normoprolactinemic patients (p<0.002). In conclusion, PCOS is associated with insulin resistance; non-obese hyperprolactinemic PCOS patients may be more insulin-resistant than normoprolactinemics and there may be an association between hyperprolactinemia and insulin resistance in PCOS. (C) 2003, Editrice Kurtis.en_US
dc.identifier.doi10.1007/BF03347025
dc.identifier.endpage659en_US
dc.identifier.issn0391-4097
dc.identifier.issue7en_US
dc.identifier.pmid14594118
dc.identifier.scopus2-s2.0-0142088910
dc.identifier.scopusqualityQ1
dc.identifier.startpage655en_US
dc.identifier.urihttps://doi.org/10.1007/BF03347025
dc.identifier.urihttps://hdl.handle.net/11468/14210
dc.identifier.volume26en_US
dc.identifier.wosWOS:000185781300012
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherEditrice Kurtis S R Len_US
dc.relation.ispartofJournal of Endocrinological Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPolycystic Ovary Syndromeen_US
dc.subjectProlactinen_US
dc.subjectHomaen_US
dc.subjectFree Androgen Indexen_US
dc.subjectInsulin Resistanceen_US
dc.titleIs hyperprolactinemia associated with insulin resistance in non-obese patients with polycystic ovary syndrome?en_US
dc.titleIs hyperprolactinemia associated with insulin resistance in non-obese patients with polycystic ovary syndrome?
dc.typeArticleen_US

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