Insecticide imidacloprid influences cognitive functions and alters learning performance and related gene expression in a rat model

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dc.contributor.authorKara, Murat
dc.contributor.authorYumrutas, Onder
dc.contributor.authorDemir, Caner F.
dc.contributor.authorOzdemir, Hasan Huseyin
dc.contributor.authorBozgeyik, Ibrahim
dc.contributor.authorCoskun, Salih
dc.contributor.authorEraslan, Ersen
dc.date.accessioned2024-04-24T17:11:28Z
dc.date.available2024-04-24T17:11:28Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe potential toxic effects of several pesticides, including imidacloprid on non-target organisms have not been clearly established. Also, the chronic effects of non-toxic doses on cognitive function in mammals are unknown. In this study, the effects of different doses of imidacloprid on learning and memory of infant and adult rats were evaluated, and the expressions of genes synthesizing proteins known to be associated with learning in brain tissues were also documented. 0.5, 2 and 8 mg/kg doses of imidacloprid were administered to newborn infant and adult Wistar albino rats by gavage. Their learning activities were evaluated, and the expression levels of the inotropic glutamate receptor GRIN1, synoptophysin, growth-associated protein 43 and the muscarinic receptor M1 in hippocampus were determined by real-time PCR method. Learning activities were diminished significantly at 2 and 8 mg/kg doses in the infant model groups and at 8 mg/kg dose in adult rats. Also, expression levels of GRIN1, SYP and GAP-43 were found to be insignificantly altered. Only the expression of M1 were significantly changed in high doses of adult group. Thus imidacloprid in high doses causes deterioration in cognitive functions particularly in infant rats, and this deterioration may be associated with changes in the expressions of related genes.en_US
dc.description.sponsorshipScientific Research Projects Coordination Unit of Firat University [TF.12.70]en_US
dc.description.sponsorshipThis work was supported by Scientific Research Projects Coordination Unit of Firat University with the project number TF.12.70.en_US
dc.identifier.doi10.1111/iep.12139
dc.identifier.endpage337en_US
dc.identifier.issn0959-9673
dc.identifier.issn1365-2613
dc.identifier.issue5en_US
dc.identifier.pmid26568164
dc.identifier.scopus2-s2.0-84983133949
dc.identifier.scopusqualityQ2
dc.identifier.startpage332en_US
dc.identifier.urihttps://doi.org/10.1111/iep.12139
dc.identifier.urihttps://hdl.handle.net/11468/17535
dc.identifier.volume96en_US
dc.identifier.wosWOS:000367324300008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal of Experimental Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCognitive Functionen_US
dc.subjectGap-43en_US
dc.subjectGrin 1en_US
dc.subjectImidaclopriden_US
dc.subjectSynaptophysinen_US
dc.subjectToxic Effectsen_US
dc.titleInsecticide imidacloprid influences cognitive functions and alters learning performance and related gene expression in a rat modelen_US
dc.titleInsecticide imidacloprid influences cognitive functions and alters learning performance and related gene expression in a rat model
dc.typeArticleen_US

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