Protective effects of ginseng extracts and common anti-aggregant drugs on ischaemia-reperfusion injury

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dc.contributor.authorCaliskan, Ahmet
dc.contributor.authorKarahan, Oguz
dc.contributor.authorYazici, Suleyman
dc.contributor.authorDemirtas, Sinan
dc.contributor.authorGuclu, Orkut
dc.contributor.authorTezcan, Orhan
dc.contributor.authorYavuz, Celal
dc.date.accessioned2024-04-24T17:28:05Z
dc.date.available2024-04-24T17:28:05Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Ginseng is a traditional herbal medicinal product widely used for various types of diseases because of its cellular protective effects. Possible protective effects of ginseng were investigated in blood, cardiac and renal tissue samples and compared with common anti-aggregant agents in an animal ischaemia-reperfusion (I/R) model. Methods: Twenty rats were equally divided into four different groups as follows: control group (I/R-induced group without drug use), group I (acetylsalicylic acid-administered group), group II (clopidogrel bisulfate-administered group), group III (ginsenoside Rb-1-administered group). For the groups assigned to a medication, peripheral I/R was induced by clamping the femoral artery one week after initiation of the specified medication. After reperfusion was initiated, cardiac and renal tissues and blood samples were obtained from each rat with subsequent analysis of nitrogen oxide (NOx), malondialdehyde (MDA), paraoxonase 1 (PON1) and prolidase. Results: NOx levels were similar in each group. Significant decrements were observed in serum PON1 levels in each group when compared with the control (p < 0.05). Serum MDA levels were significantly lower in groups II and III (p < 0.05). Ameliorated renal prolidase levels were detected in study groups (p < 0.05) and recovered cardiac prolidase levels were obtained in groups II and III (p < 0.05). Conclusion: These findings indicate that ginseng extracts may have a potential beneficial effect in I/R injury. However, more comprehensive studies are required to clarify the hypothetical cardiac, renal and systemic protective effects in reperfusion-induced oxidative damage.en_US
dc.description.sponsorshipDicle University DUBAPen_US
dc.description.sponsorshipWe are grateful to Dicle University DUBAP for their sponsorship of the English editing of this manuscript.en_US
dc.identifier.doi10.5830/CVJA-2015-047
dc.identifier.endpage226en_US
dc.identifier.issn1995-1892
dc.identifier.issn1680-0745
dc.identifier.issue6en_US
dc.identifier.pmid26659436
dc.identifier.scopus2-s2.0-84954497691
dc.identifier.scopusqualityQ3
dc.identifier.startpage222en_US
dc.identifier.urihttps://doi.org/10.5830/CVJA-2015-047
dc.identifier.urihttps://hdl.handle.net/11468/20321
dc.identifier.volume26en_US
dc.identifier.wosWOS:000369241000012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherClinics Cardive Publ Pty Ltden_US
dc.relation.ispartofCardiovascular Journal of Africa
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGinsengen_US
dc.subjectHerbal Medicineen_US
dc.subjectAnti-Aggregant Drugsen_US
dc.subjectIschaemia-Reperfusion Injuryen_US
dc.titleProtective effects of ginseng extracts and common anti-aggregant drugs on ischaemia-reperfusion injuryen_US
dc.titleProtective effects of ginseng extracts and common anti-aggregant drugs on ischaemia-reperfusion injury
dc.typeArticleen_US

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