Protective effect of ethyl pyruvate on liver injury in streptozotocin-induced diabetic rats

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dc.contributor.authorAkkoc, H.
dc.contributor.authorKelle, I.
dc.contributor.authorTunik, S.
dc.contributor.authorBahceci, S.
dc.contributor.authorSencar, L.
dc.contributor.authorAyaz, E.
dc.contributor.authorNergiz, Y.
dc.date.accessioned2024-04-24T17:37:51Z
dc.date.available2024-04-24T17:37:51Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground and aims : Diabetes Mellitus, leading to an increase in oxidative stress, can cause liver damage. Our aim was to investigate the antioxidant effects of Ethyl Pyruvate (EP) on the liver tissue in diabetic rats. Materials and methods : Thirty-two Wistar albino rats were separated into four equal groups. Groups were assigned as follows : (1) Non-diabetic group; (2) EP-treated non-diabetic group; (3) diabetic group; and (4) EP-treated diabetic group. In order to induce diabetes mellitus, 45 mg/kg b.w. streptozotocin was administered intraperitoneally to the rats in groups 3 and 4. On the 3rd day, blood glucose was assessed. Rats with blood glucose levels higher than 300 mg/dl were considered to be diabetic. The EP solution was administered intraperitoneally at a dose of 50 mg/kg b.w. twice daily for 14 days to the rats in groups 2 and 4. The other rats were simultaneously given the same amount of Ringer's lactate solution intraperitoneally. Liver tissue was obtained for malondialdehyde (MDA) analyses and histopathological examination. Results : In group 4, Total Antioxidant Status (TOS) and MDA levels were significantly lower as compared to group 3. Also, morphological abnormalities occurred in group 3 when compared with non-diabetic groups (groups 1 and 2), whereas the disorders resulting from diabetes improved significantly in group 4. Conclusions : These findings show that EP has protective effects against diabetes-induced liver injury. (Acta gastroenterol. belg, 2012. 75, 336-341).en_US
dc.identifier.endpage341en_US
dc.identifier.issn0001-5644
dc.identifier.issue3en_US
dc.identifier.pmid23082705
dc.identifier.scopus2-s2.0-84867307581
dc.identifier.scopusqualityQ3
dc.identifier.startpage336en_US
dc.identifier.urihttps://hdl.handle.net/11468/21217
dc.identifier.volume75en_US
dc.identifier.wosWOS:000311467600008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherUniv Catholique Louvain-Uclen_US
dc.relation.ispartofActa Gastro-Enterologica Belgica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetic Liver Injuryen_US
dc.subjectEthyl Pyruvateen_US
dc.subjectStreptozotocinen_US
dc.subjectOxidative Stressen_US
dc.titleProtective effect of ethyl pyruvate on liver injury in streptozotocin-induced diabetic ratsen_US
dc.titleProtective effect of ethyl pyruvate on liver injury in streptozotocin-induced diabetic rats
dc.typeArticleen_US

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