Effects of heparin fractions on the prevention of skin necrosis resulting from adriamycin extravasation: An experimental study

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dc.contributor.authorAskar, I
dc.contributor.authorErbas, MK
dc.contributor.authorGurlek, A
dc.date.accessioned2024-04-24T17:08:09Z
dc.date.available2024-04-24T17:08:09Z
dc.date.issued2002
dc.departmentDicle Üniversitesien_US
dc.description.abstractExtravasation of a chemotherapeutic agent is one of the most frequent complications in cancer patients. Full-thickness skin necrosis often occurs after extravasation. Alternative approaches to treatment are local wound care, elevation, and hypothermia. It was shown that heparin prevents skin necrosis. In this experimental study, the effects of heparin fractions on the prevention of skin necrosis were compared by applying an extravasation model of Adriamycin in rats. Forty Sprague-Dawley male rats weighing 250 to 300 g were used. A total of 0.3 ml doxorubicin hydrochloride was administered subcutaneously to all rats. Ten minutes later, in the control group (group 1), 1 ml normal saline was administered subcutaneously. In the first experimental group (group 11), 100 U per day heparin sodium was administered in a volume of 1 ml subcutaneously. In the second experimental group (group III), nadroparin calcium (5 anti-Xa U per kilogram per day) was administered. In the third and last experimental group (group IV), dalteparin sodium (5 anti-Xa U per kilogram per day) was administered. All drugs were administered for 2 weeks. Necrotic areas were measured 4 weeks later. Statistical analysis was performed using the Kruskal-Wallis analysis of variance and the Mann-Whitney U test. Heparin fractions caused a decreased ulcer rate and size than controls (p < 0.05). There was no superiority among heparin fractions. The authors think that low-molecular weight heparins are preferred, considering the higher risk of bleeding with unfractionated heparin.en_US
dc.identifier.doi10.1097/00000637-200209000-00010
dc.identifier.endpage301en_US
dc.identifier.issn0148-7043
dc.identifier.issn1536-3708
dc.identifier.issue3en_US
dc.identifier.pmid12351979
dc.identifier.scopus2-s2.0-0036714349
dc.identifier.scopusqualityQ2
dc.identifier.startpage297en_US
dc.identifier.urihttps://doi.org/10.1097/00000637-200209000-00010
dc.identifier.urihttps://hdl.handle.net/11468/17224
dc.identifier.volume49en_US
dc.identifier.wosWOS:000177921600012
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAnnals of Plastic Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleEffects of heparin fractions on the prevention of skin necrosis resulting from adriamycin extravasation: An experimental studyen_US
dc.titleEffects of heparin fractions on the prevention of skin necrosis resulting from adriamycin extravasation: An experimental study
dc.typeArticleen_US

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