Effects of dietary boron on cervical cytopathology and on micronucleus frequency in exfoliated buccal cells

Basit Öğe Kaydı
dc.contributor.authorKorkmaz, Mehmet
dc.contributor.authorUzgören, Engin
dc.contributor.authorBakirdere, Sezgin
dc.contributor.authorAydın, Fırat
dc.contributor.authorAtaman, O. Yavuz
dc.date.accessioned2024-04-24T15:59:33Z
dc.date.available2024-04-24T15:59:33Z
dc.date.issued2007
dc.departmentDicle Üniversitesi, Fen-Edebiyat Fakültesi, Kimya Bölümüen_US
dc.description.abstractRecent evidence indicates that boron and borates may have anticarcinogenic properties. In this study, we have investigated the incidence of adverse cytological findings in cervical smears and the micronucleus (MN) frequency in women living in boron-rich and boron-poor regions. Cervical smears were prepared from 1059 women with low socioeconomic status; 472 of the women lived in relatively boron-rich rural areas, while 587 lived in relatively boron-poor regions. The average and standard deviation values for the age of the women screened with the cervical Pap smear test were 41.55 +/- 8.38. The mean dietary intake of boron was 8.41 mg/day for women from the boron-rich regions, and 1.26 mg/day for women living in the boron-poor regions (P < 0.0001). Women from the boron-rich regions had no cytopathological indications of cervical cancer, while there were cytopathological findings for 15 women from the boron-poor areas (chi(2) = - 10.473, P < 0.05). Sixty women, 30 from each region, were chosen for evaluating MN frequencies in exfoliated buccal cells. MN frequencies for women from the boron-rich and boron-poor regions were not significantly different (t = -0.294, P > 0.05). Also, there were no significant correlations between age and MN frequency for women from both the boron-rich (r = 0.133, P = 0.48, P > 0.05) and boron-poor (r = -0.033, P = 0.861, P > 0.05) regions. The results suggest that ingestion of boron in the drinking water decreases the incidence of cervical cancer-related histopathological findings. There was no correlation between the pathological findings from the cervical smears and buccal cell MN frequency suggesting that the two study populations were exposed equally to gentotoxic agents. Nonetheless, cervical cancer-related histopathological findings should be validated by other researchers. (c) 2007 Wiley Periodicals, Inc.en_US
dc.description.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1002/tox.20229
dc.identifier.citationKorkmaz, M., Uzgören, E., Bakirdere, S., Aydın, F. ve Ataman, O.Y. (2007). Effects of dietary boron on cervical cytopathology and on micronucleus frequency in exfoliated buccal cells. Environmental Toxicology, 22(1), 17–25.
dc.identifier.doi10.1002/tox.20229
dc.identifier.endpage25en_US
dc.identifier.issn1520-4081
dc.identifier.issn1522-7278
dc.identifier.issue1en_US
dc.identifier.pmid17295277
dc.identifier.scopus2-s2.0-33847218316
dc.identifier.scopusqualityQ1
dc.identifier.startpage17en_US
dc.identifier.urihttps://doi.org/10.1002/tox.20229
dc.identifier.urihttps://hdl.handle.net/11468/14138
dc.identifier.volume22en_US
dc.identifier.wosWOS:000244378400003
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAydın, Fırat
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofEnvironmental Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBoronen_US
dc.subjectCervical Canceren_US
dc.subjectAnticarcinogenic agentsen_US
dc.subjectPapanicolau smearen_US
dc.subjectMicronucleus testen_US
dc.titleEffects of dietary boron on cervical cytopathology and on micronucleus frequency in exfoliated buccal cellsen_US
dc.titleEffects of dietary boron on cervical cytopathology and on micronucleus frequency in exfoliated buccal cells
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Kimya Bölümü Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu