Sheehan's syndrome as a rare cause of anaemia secondary to hypopituitarism

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dc.contributor.authorGokalp, Deniz
dc.contributor.authorTuzcu, Alpaslan
dc.contributor.authorBahceci, Mithat
dc.contributor.authorArikan, Senay
dc.contributor.authorBahceci, Selen
dc.contributor.authorPasa, Semir
dc.date.accessioned2024-04-24T16:00:02Z
dc.date.available2024-04-24T16:00:02Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractAlthough its exact mechanism is unclear, anaemia is well recognised as a feature of hypopituitarism; and anaemia is associated with Sheehan's syndrome (SS). We aimed to evaluate the frequency and severity of anaemia and other haematological changes among patients with Sheehan's syndrome, in comparison with healthy controls. Sixty-five SS patients and 55 age-matched female healthy controls were included. Biochemical and hormonal assessments and haematological evaluations were carried out, and groups were compared. The mean number of red blood cells, as well as mean haemoglobin, iron and erythropoietin levels, total iron-binding capacity and transferrin saturation were all significantly lower in SS patients compared to controls. SS patients had significantly higher rates of anaemia (80.0% vs. 25.5%, p = 0.0001), iron deficiency (44.6% vs. 5.4%, p = 0.001), leukopenia (20.0% vs. 5.4%, p = 0.015), thrombocytopenia (9.2% vs. 0.0%, p = 0.028) and bicytopenia (21.5% vs. 1.8%, p = 0.001) compared to controls. Anaemic SS patients had normochromic-normocytic anaemia (55%) or hypochromic-microcytic anaemia (45%). Anaemia is frequently associated with Sheehan's syndrome and responds to appropriate replacement therapy. Hypopituitarism should be considered as a possible cause of anaemia, and a hormone examination should be undertaken promptly, particularly in patients with anaemia resistant to therapy and/or with a history suggestive of Sheehan's syndrome.en_US
dc.identifier.doi10.1007/s00277-008-0607-4
dc.identifier.endpage410en_US
dc.identifier.issn0939-5555
dc.identifier.issue5en_US
dc.identifier.pmid18797868
dc.identifier.scopus2-s2.0-63649153738
dc.identifier.scopusqualityQ2
dc.identifier.startpage405en_US
dc.identifier.urihttps://doi.org/10.1007/s00277-008-0607-4
dc.identifier.urihttps://hdl.handle.net/11468/14348
dc.identifier.volume88en_US
dc.identifier.wosWOS:000264316800002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAnnals of Hematology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSheehan's Syndromeen_US
dc.subjectAnaemiaen_US
dc.subjectHypopituitarismen_US
dc.subjectHormone Replacement Therapyen_US
dc.titleSheehan's syndrome as a rare cause of anaemia secondary to hypopituitarismen_US
dc.titleSheehan's syndrome as a rare cause of anaemia secondary to hypopituitarism
dc.typeArticleen_US

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