MRI-based evaluation of the factors leading to pituitary iron overload in patients with thalassemia major

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dc.contributor.authorCetincakmak, Mehmet Guli
dc.contributor.authorHattapoglu, Salih
dc.contributor.authorMenzilcioglu, Sait
dc.contributor.authorAlan, Bircan
dc.contributor.authorUluca, Unal
dc.contributor.authorUcar, Ahmet
dc.contributor.authorSoker, Murat
dc.date.accessioned2024-04-24T16:15:44Z
dc.date.available2024-04-24T16:15:44Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: Given the lack of studies evaluating pituitary iron overload in patients with thalassemia major, we used magnetic resonance imaging (MRI) to evaluate these patients and the factors affecting the disease process. Materials and methods: The 84 patients with beta-thalassemia major who were included in this study were referred to our clinic for cardiac and hepatic T2* MRI. T2*-weighted images of the pituitary gland, heart, and liver were obtained using a 1.5-tesla MRI unit and a multi-echo gradient-echo sequence. Associations between pituitary T2*, cardiac T2*, hepatic T2*, pituitary height, serum ferritin (SF) level, patient age, and other demographic findings were assessed. Results: Pituitary T2* values correlated with hepatic TZ values, cardiac T2* values, SF level, and patient age (P <= 0.001, 0.001, 0.001, 0.01, respectively) but not with pituitary height (P=0.76). Pituitary and cardiac T2* values were lower in the subset of patients who underwent splenectomy (P=0.046 and P= 0.002, respectively). Conclusion: Pituitary iron overload rapidly increases during puberty and in this study correlated with cardiac and hepatic T2* values, patient age, SF level, and liver size, but not with the height of the pituitary. Pituitary iron overload also increases following splenectomy. Together, these findings indicate that numerous factors contribute to pituitary iron overload. (C) 2016 Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.neurad.2016.03.001
dc.identifier.endpage302en_US
dc.identifier.issn0150-9861
dc.identifier.issn1773-0406
dc.identifier.issue4en_US
dc.identifier.pmid27083690en_US
dc.identifier.scopus2-s2.0-84964322459en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage297en_US
dc.identifier.urihttps://doi.org/10.1016/j.neurad.2016.03.001
dc.identifier.urihttps://hdl.handle.net/11468/15909
dc.identifier.volume43en_US
dc.identifier.wosWOS:000381175100009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherMasson Editeuren_US
dc.relation.ispartofJournal of Neuroradiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThalassemiaen_US
dc.subjectPituitaryen_US
dc.subjectIron Overloaden_US
dc.subjectMr Imagingen_US
dc.titleMRI-based evaluation of the factors leading to pituitary iron overload in patients with thalassemia majoren_US
dc.typeArticleen_US

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