The effects of valproic acid, vitamin E and folic acid on ribs of rat fetuses in the prenatal period

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dc.contributor.authorBaran, Ö
dc.contributor.authorNergiz, Y
dc.contributor.authorTuncer, MC
dc.date.accessioned2024-04-24T16:10:42Z
dc.date.available2024-04-24T16:10:42Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe present study was undertaken to determine histopathologic differences in the ribs of Wistar-albino rat fetuses prenatally exposed to valproic acid (VPA), folic acid (FA) and vitamin E (Vit E), and to compare their differential developmental susceptibility and morphological association with skeletal anomalies. VPA (300mg/kg), FA (300mg/kg) and Vit E (250mg/kg) were administered to rats on each of gestation days (GD) 7-9. Fetuses were collected on GD 21 and their ribs were examined for malformations. The fetuses were divided into four groups: blind-trial group, VPA group (vpa), VPA and Vit E group (vpa+vit e), valproic and FA group (vpa+fa). In each group; drug procedure, surgical procedure and histological methods were performed. Later, weights and lengths of fetuses in each group were compared and analyzed by one-way Anova test. As a result, malformations in fetuses were determined and photographed by Nikon SMZ-2 steromicroscopy, using 2 x objective. Administration of single doses of VPA (300 mg/kg) resulted in weight and length loss between blind-trial and vpa group. However, length and weight differences between the other groups were not significant. The objective of the present study is to analyze morphological and histopathologic changes which may occur in a high-risk experimental model after the administration of VPA. In addition, protective roles of the administration of FA and Vit E are assessed. (c) 2005 Elsevier GmbH. All rights reserved.en_US
dc.identifier.doi10.1016/j.aanat.2005.11.010
dc.identifier.endpage125en_US
dc.identifier.issn0940-9602
dc.identifier.issn1618-0402
dc.identifier.issue2en_US
dc.identifier.pmid16551008
dc.identifier.scopus2-s2.0-33644770386
dc.identifier.scopusqualityQ2
dc.identifier.startpage117en_US
dc.identifier.urihttps://doi.org/10.1016/j.aanat.2005.11.010
dc.identifier.urihttps://hdl.handle.net/11468/15047
dc.identifier.volume188en_US
dc.identifier.wosWOS:000235890300003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Gmbhen_US
dc.relation.ispartofAnnals of Anatomy-Anatomischer Anzeiger
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectValproic Aciden_US
dc.subjectVitamin Een_US
dc.subjectFolic Aciden_US
dc.subjectDouble Skeletal Stainingen_US
dc.subjectRaten_US
dc.titleThe effects of valproic acid, vitamin E and folic acid on ribs of rat fetuses in the prenatal perioden_US
dc.titleThe effects of valproic acid, vitamin E and folic acid on ribs of rat fetuses in the prenatal period
dc.typeArticleen_US

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