The potential role of BMI, plasma leptin, nesfatin-1 and ghrelin levels in the early detection of pancreatic necrosis and severe acute pancreatitis: A prospective cohort study

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dc.contributor.authorTurkoglu, Ahmet
dc.contributor.authorBoyuk, Abdullah
dc.contributor.authorTanriverdi, Mehmet Halis
dc.contributor.authorGunduz, Ercan
dc.contributor.authorDusak, Abdurrahim
dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorGumus, Metehan
dc.date.accessioned2024-04-24T16:14:56Z
dc.date.available2024-04-24T16:14:56Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Early prediction of disease severity in acute pancreatitis (AP) is crucial. The aim of this study was to investigate the body-mass index (BMI), plasma leptin, nesfatin-1 and ghrelin levels as potential markers predicting peripancreatic necrosis and severity in acute pancreatitis. Methods: In the study period, 97 consecutive patients with AP were prospectively analysed. Severe AP was defined according to the Atlanta Criteria. BMI was also calculated. To measure plasma Leptin, Nesfatin-1 and Ghrelin concentrations, the blood samples were obtained from patients within 24 hours of admission. Results: Out of 97 patients, 92(70 females, 22 males) were considered eligible for analysis. Of the 92 patients, 30 patients (32.6%) were assessed as severe pancreatitis. BMI and leptin levels were significantly higher in patients with severe pancreatitis. The pooled sensitivity and specificity of BMI as a predictor for the development of pancreatic necrosis were 0.90(95% CI = 0.56-0.99) and 0.70(95% CI = 0.58-0.79), respectively; with an overall area under curve value of 0.78. The pooled sensitivity and specificity of leptin levels as a predictor for development of pancreatic necrosis were 1(95% CI = 0.69-1) and 0.73(95% CI = 0.62-0.82), respectively; with an overall area under curve value of 0.82. Nesfatin-1 and ghrelin levels showed no significant difference in patients with mild pancreatitis (6.97 +/- 0.84 ng/ml and 2.3(1.0-9.9); respectively) and severe pancreatitis (6.74 +/- 0.65 ng/ml and 2.0(1.9-9.9); respectively) (p = 0.1923 and 0.8531; respectively). Conclusion: BMI and plasma leptin levels both were correlated with the severity of pancreatitis. Leptin levels showed better area under the curve, sensitivity and specificity values compared to BMI in prediction of pancreatic necrosis. Nesfatin-1 and ghrelin levels were not found to be predictors of the severity of disease. (C) 2014 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipProjects of Dicle University (DUBAP) [10-TF-49]en_US
dc.description.sponsorshipProjects of Dicle University (DUBAP; project no. 10-TF-49) for supporting this study.en_US
dc.identifier.doi10.1016/j.ijsu.2014.10.040
dc.identifier.endpage1313en_US
dc.identifier.issn1743-9191
dc.identifier.issn1743-9159
dc.identifier.issue12en_US
dc.identifier.pmid25448651
dc.identifier.scopus2-s2.0-84918836049
dc.identifier.scopusqualityQ1
dc.identifier.startpage1310en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijsu.2014.10.040
dc.identifier.urihttps://hdl.handle.net/11468/15526
dc.identifier.volume12en_US
dc.identifier.wosWOS:000346646600013
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofInternational Journal of Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Pancreatitisen_US
dc.subjectLeptinen_US
dc.subjectNesfatin-1en_US
dc.subjectGhrelinen_US
dc.subjectBmien_US
dc.titleThe potential role of BMI, plasma leptin, nesfatin-1 and ghrelin levels in the early detection of pancreatic necrosis and severe acute pancreatitis: A prospective cohort studyen_US
dc.titleThe potential role of BMI, plasma leptin, nesfatin-1 and ghrelin levels in the early detection of pancreatic necrosis and severe acute pancreatitis: A prospective cohort study
dc.typeArticleen_US

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