Proton T1 and T2 relaxivities of serum proteins

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dc.contributor.authorYilmaz, A
dc.contributor.authorUlak, FS
dc.contributor.authorBatun, MS
dc.date.accessioned2024-04-24T16:15:38Z
dc.date.available2024-04-24T16:15:38Z
dc.date.issued2004
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn the present study, T-1 and T-2 of phantoms containing serum sets with varying amounts of proteins, serum samples with certain amounts of proteins, serum diluted by distilled water, and serum treated with iron were measured. In addition, T-1 and T-2 of phantoms containing normal serum, diluted serum, and albumin-doped serum were also measured. Relaxation rates were plotted versus protein concentrations. The slope of relation was taken as relaxivity. The T-1 relaxivities of proteins were ranged from 0.035 to 0.080 s(-1)(g/dl)(-1), whereas T-2 relaxivities were ranged from 0.24 to 0.68 s(-1)(g/dl)(-1). The T-1 and T-2 relaxivities of transferrin iron were 2.40 and 2.60 mM(-1)s(-1), respectively. The contributions of diamagnetic proteins and transferrin iron to the relaxation rate of serum were also calculated for each of diluted serum, normal and albumin-doped serum. The contributions and the average TP relaxivities(calculated by using individual relaxivities and the ratios of protein fractions in TP) were used for TP calculations. The agreement between the calculated TP and TP by autoanalyzer and also the agreement between average TP relaxivities and the TP relaxivities determined from dilution experiments show that the data of relaxivities are reliable. The results suggest that individual protein relaxivities explain the influence of serum TP composition on T-1 and T-2 relaxation times. (C) 2004 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.mri.2004.02.001
dc.identifier.endpage688en_US
dc.identifier.issn0730-725X
dc.identifier.issue5en_US
dc.identifier.pmid15172062
dc.identifier.scopus2-s2.0-2542498743
dc.identifier.scopusqualityQ2
dc.identifier.startpage683en_US
dc.identifier.urihttps://doi.org/10.1016/j.mri.2004.02.001
dc.identifier.urihttps://hdl.handle.net/11468/15878
dc.identifier.volume22en_US
dc.identifier.wosWOS:000221688400011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofMagnetic Resonance Imaging
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMrien_US
dc.subjectT-1en_US
dc.subjectT-2en_US
dc.subjectRelaxivityen_US
dc.subjectProteinsen_US
dc.titleProton T1 and T2 relaxivities of serum proteinsen_US
dc.titleProton T1 and T2 relaxivities of serum proteins
dc.typeArticleen_US

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