A High Level of Carcinoembryonic Antigen as Initial Manifestation of Medullary Thyroid Carcinoma in a Patient With Subclinical Hyperthyroidism

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dc.contributor.authorAkbulut, Sami
dc.contributor.authorSogutcu, Nilgun
dc.date.accessioned2024-04-24T17:33:08Z
dc.date.available2024-04-24T17:33:08Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractCarcinoembryonic antigen (CEA), a tumor marker with a glycoprotein structure, is frequently used in follow-up gastrointestinal malignancies. CEA levels may also increase in neuroendocrine tumors, including medullary thyroid carcinoma (MTC), and in some benign diseases. Patients whose blood tests show high CEA levels should have additional tests regarding MTC. Although MTC comprises only 3%-11% of all thyroid cancers, it should be tested because it has a poor prognosis and may accompany multiple endocrine neoplasia. We present the case of a 76-year-old man with subclinical hyperthyroidism with sporadic MTC who presented with initial high serum CEA levels. He underwent total thyroidectomy and left modified neck dissection. Pathologic specimens stained strongly for CEA. The patient's blood was analyzed for mutations in exons 10, 11, 13, 14, 15, and 16, but the RET proto-oncogene revealed no mutations. The patient was regularly followed by measurement of serum CEA levels and performance of positron emission tomography-computed tomography. Seventeen months after surgery, the patient has remained well and showed no signs of tumor recurrence.en_US
dc.identifier.doi10.9738/CC55.1
dc.identifier.endpage259en_US
dc.identifier.issn0020-8868
dc.identifier.issue3en_US
dc.identifier.pmid22216705
dc.identifier.startpage254en_US
dc.identifier.urihttps://doi.org/10.9738/CC55.1
dc.identifier.urihttps://hdl.handle.net/11468/20457
dc.identifier.volume96en_US
dc.identifier.wosWOS:000299134000012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherInt College Of Surgeonsen_US
dc.relation.ispartofInternational Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMtcen_US
dc.subjectCeaen_US
dc.subjectPet-Cten_US
dc.subjectMen-Iien_US
dc.subjectRet Proto-Oncogeneen_US
dc.titleA High Level of Carcinoembryonic Antigen as Initial Manifestation of Medullary Thyroid Carcinoma in a Patient With Subclinical Hyperthyroidismen_US
dc.titleA High Level of Carcinoembryonic Antigen as Initial Manifestation of Medullary Thyroid Carcinoma in a Patient With Subclinical Hyperthyroidism
dc.typeArticleen_US

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