A High Level of Carcinoembryonic Antigen as Initial Manifestation of Medullary Thyroid Carcinoma in a Patient With Subclinical Hyperthyroidism
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Tarih
2011
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Int College Of Surgeons
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Carcinoembryonic antigen (CEA), a tumor marker with a glycoprotein structure, is frequently used in follow-up gastrointestinal malignancies. CEA levels may also increase in neuroendocrine tumors, including medullary thyroid carcinoma (MTC), and in some benign diseases. Patients whose blood tests show high CEA levels should have additional tests regarding MTC. Although MTC comprises only 3%-11% of all thyroid cancers, it should be tested because it has a poor prognosis and may accompany multiple endocrine neoplasia. We present the case of a 76-year-old man with subclinical hyperthyroidism with sporadic MTC who presented with initial high serum CEA levels. He underwent total thyroidectomy and left modified neck dissection. Pathologic specimens stained strongly for CEA. The patient's blood was analyzed for mutations in exons 10, 11, 13, 14, 15, and 16, but the RET proto-oncogene revealed no mutations. The patient was regularly followed by measurement of serum CEA levels and performance of positron emission tomography-computed tomography. Seventeen months after surgery, the patient has remained well and showed no signs of tumor recurrence.
Açıklama
Anahtar Kelimeler
Mtc, Cea, Pet-Ct, Men-Ii, Ret Proto-Oncogene
Kaynak
International Surgery
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
96
Sayı
3
