Pulmonary Function in Patients with End-Stage Renal Disease: Effects of Hemodialysis and Fluid Overload

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dc.contributor.authorYilmaz, Sureyya
dc.contributor.authorYildirim, Yasar
dc.contributor.authorYilmaz, Zulfukar
dc.contributor.authorKara, Ali Veysel
dc.contributor.authorTaylan, Mahsuk
dc.contributor.authorDemir, Melike
dc.contributor.authorCoskunsel, Mehmet
dc.date.accessioned2024-04-24T17:15:07Z
dc.date.available2024-04-24T17:15:07Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Respiratory system disorders are one of the most prevalent complications in end-stage renal disease patients on hemodialysis. However, the pathogenesis of impaired pulmonary functions has not been completely elucidated in these patients. We designed a study to investigate acute effects of hemodialysis treatment on spirometry parameters, focusing on the relationship between pulmonary function and fluid status in hemodialysis patients. Material/Methods: We enrolled 54 hemodialysis patients in this study. Multifrequency bioimpedance analysis (BIA) was used to assess fluid status before and 30 min after the midweek of hemodialysis (HD). Overhydration (OH)/extracellular water (ECW)% ratio was used as an indicator of fluid status. Fluid overload was defined as OH/ECW 3 7%. Spirometry was performed before and after hemodialysis. Results: Forced vital capacity (FVC), FVC%, and forced expiratory volume in the first second (FEV1) levels were significantly increased after hemodialysis. FVC, FVC%, FEV1, FEV1%, mean forced expiratory flow between 25% and 75% of the FVC (FEF25-75), FEF25-75%, peak expiratory flow rate (PEFR), and PEFR% were significantly lower in patients with fluid overload than in those without. OH/ECW ratio was negatively correlated with FVC, FVC%, FEV1, FEV1%, FEF25-75, FEF25-75%, PEFR, and PEFR%. Stepwise multiple regression analysis revealed that male sex and increased ultrafiltration volume were independently associated with higher FVC, whereas increased age and OH/ECW ratio were independently associated with lower FVC. Conclusions: Fluid overload is closely associated with restrictive and obstructive respiratory abnormalities in HD patients. In addition, hemodialysis has a beneficial effect on pulmonary function tests, which may be due to reduction of volume overload.en_US
dc.identifier.doi10.12659/MSM.897480
dc.identifier.endpage2784en_US
dc.identifier.issn1643-3750
dc.identifier.pmid27497672
dc.identifier.scopus2-s2.0-84983410521
dc.identifier.scopusqualityQ1
dc.identifier.startpage2779en_US
dc.identifier.urihttps://doi.org/10.12659/MSM.897480
dc.identifier.urihttps://hdl.handle.net/11468/18341
dc.identifier.volume22en_US
dc.identifier.wosWOS:000381309800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherInt Scientific Information, Incen_US
dc.relation.ispartofMedical Science Monitor
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectElectric Impedanceen_US
dc.subjectRenal Dialysisen_US
dc.subjectRenal Insufficiencyen_US
dc.subjectChronicen_US
dc.subjectRespiratory Function Testsen_US
dc.titlePulmonary Function in Patients with End-Stage Renal Disease: Effects of Hemodialysis and Fluid Overloaden_US
dc.titlePulmonary Function in Patients with End-Stage Renal Disease: Effects of Hemodialysis and Fluid Overload
dc.typeArticleen_US

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