Association between sequence variations of the Mediterranean fever gene and the risk of migraine: a case-control study

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dc.contributor.authorCoskun, Salih
dc.contributor.authorVarol, Sefer
dc.contributor.authorOzdemir, Hasan H.
dc.contributor.authorCelik, Sercan Bulut
dc.contributor.authorBalduz, Metin
dc.contributor.authorCamkurt, Mehmet Akif
dc.contributor.authorCim, Abdullah
dc.date.accessioned2024-04-24T17:18:28Z
dc.date.available2024-04-24T17:18:28Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractMigraine pathogenesis involves a complex interaction between hormones, neurotransmitters, and inflammatory pathways, which also influence the migraine phenotype. The Mediterranean fever gene (MEFV) encodes the pyrin protein. The major role of pyrin appears to be in the regulation of inflammation activity and the processing of the cytokine prointerleukin-1 beta, and this cytokine plays a part in migraine pathogenesis. This study included 220 migraine patients and 228 healthy controls. Eight common missense mutations of the MEFV gene, known as M694V, M694I, M680I, V726A, R761H, K695R, P369S, and E148Q, were genotyped using real-time polymerase chain reaction with 5' nuclease assays, which include sequence specific primers, and probes with a reporter dye. When mutations were evaluated separately among the patient and control groups, only the heterozygote E148Q carrier was found to be significantly higher in the control group than in the patient group (P=0.029, odds ratio [95% confidence interval] =0.45 [0.21-0.94]). In addition, the frequency of the homozygote and the compound heterozygote genotype carrier was found to be significantly higher in patients (n=8, 3.6%) than in the control group (n=1, 0.4%) (P=0.016, odds ratio [95% confidence interval] =8.57 [1.06-69.07]). However, there was no statistically significant difference in the allele frequencies of MEFV mutations between the patients and the healthy control group (P=0.964). In conclusion, the results of the present study suggest that biallelic mutations in the MEFV gene could be associated with a risk of migraine in the Turkish population. Moreover, MEFV mutations could be related to increased frequency and short durations of migraine attacks (P=0.043 and P=0.021, respectively). Future studies in larger groups and expression analysis of MEFV are required to clarify the role of the MEFV gene in migraine susceptibility.en_US
dc.description.sponsorshipDicle University Scientific Research Projects Coordination Office (DUBAP) [14-TF-106]en_US
dc.description.sponsorshipThis research article is supported by Dicle University Scientific Research Projects Coordination Office (DUBAP, Project No 14-TF-106).en_US
dc.identifier.doi10.2147/NDT.S109414
dc.identifier.endpage2232en_US
dc.identifier.issn1178-2021
dc.identifier.pmid27621632
dc.identifier.scopus2-s2.0-84985991883
dc.identifier.scopusqualityQ2
dc.identifier.startpage2225en_US
dc.identifier.urihttps://doi.org/10.2147/NDT.S109414
dc.identifier.urihttps://hdl.handle.net/11468/18794
dc.identifier.volume12en_US
dc.identifier.wosWOS:000382218600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofNeuropsychiatric Disease and Treatment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMefv Geneen_US
dc.subjectHeadacheen_US
dc.subjectFamilial Mediterranean Fever (Fmf)en_US
dc.subjectBiallelic Mutationsen_US
dc.subjectPyrin (Or Marenostrin)en_US
dc.subjectAuraen_US
dc.subjectSingle Nucleotide Polymorphismsen_US
dc.titleAssociation between sequence variations of the Mediterranean fever gene and the risk of migraine: a case-control studyen_US
dc.titleAssociation between sequence variations of the Mediterranean fever gene and the risk of migraine: a case-control study
dc.typeArticleen_US

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