Increased bone mineral density in patients with non-alcoholic steatohepatitis

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dc.contributor.authorKaya, Muhsin
dc.contributor.authorIsik, Devran
dc.contributor.authorBestas, Remzi
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorAkpolat, Veysi
dc.contributor.authorBuyukbayram, Huseyin
dc.contributor.authorKaplan, Mehmet Ali
dc.date.accessioned2024-04-24T17:24:22Z
dc.date.available2024-04-24T17:24:22Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractAIM: To determine the relationship between non-alcoholic steatohepatitis (NASH) and bone mineral density (BMD). METHODS: A total of 38 patients (25 males) with a diagnosis of histologically proven NASH and 42 healthy controls (24 males) were enrolled in the study. Demographic features, clinical findings, complete blood count and routine biochemical analysis, as well as adrenal, thyroid and gonadal functions, were recorded. Additionally, intact parathormone, 25-OH-vitamin-D3, tumor necrosis factor-alpha, interleukin-6, interleukin-1, in-sulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels were measured in both groups. Furthermore, lumbar spine and femoral neck BMD of both groups were measured by the dual-energy X-ray absorptiometry (DXA) method. RESULTS: The mean age was 41 +/- 12 years in the NASH group and 43 +/- 11 years in the control group. Among demographic features, waist circumference was significantly larger in the NASH group compared to the control group (P < 0.019). Among laboratory parameters, serum triglyceride (P < 0.008), alanine transaminase (P < 0.0001), aspartate transaminase (P < 0.001), alkaline phosphatase (P < 0.016), gamma glutamyl transferase (P < 0.0001), ferritin (P < 0.001) and 25-OH-vitamin-D3 levels (P < 0.0001) were significantly higher in the NASH group compared to the control group. Lumbar BMD was significantly higher in the NASH group compared to the control group (1.057 +/- 0.119 g/cm(2) vs 0.941 +/- 0.133 g/cm(2); P < 0.001, respectively). In the NASH group, there was no significant relationship between BMD and fibrosis stage in liver biopsy. CONCLUSION: NASH increases BMD and may be related to an elevated serum 25-OH-vitamin D3 level. (C) 2013 Baishideng Publishing Group Co., Limited. All rights reserved.en_US
dc.identifier.doi10.4254/wjh.v5.i11.627
dc.identifier.endpage634en_US
dc.identifier.issn1948-5182
dc.identifier.issue11en_US
dc.identifier.pmid24303091
dc.identifier.scopus2-s2.0-84890669989
dc.identifier.scopusqualityQ2
dc.identifier.startpage627en_US
dc.identifier.urihttps://doi.org/10.4254/wjh.v5.i11.627
dc.identifier.urihttps://hdl.handle.net/11468/19641
dc.identifier.volume5en_US
dc.identifier.wosWOS:000439169500004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBaishideng Publishing Group Incen_US
dc.relation.ispartofWorld Journal of Hepatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNon-Alcoholic Steatohepatitisen_US
dc.subjectHepatic Osteodystrophyen_US
dc.subjectBone Mineral Densityen_US
dc.titleIncreased bone mineral density in patients with non-alcoholic steatohepatitisen_US
dc.titleIncreased bone mineral density in patients with non-alcoholic steatohepatitis
dc.typeArticleen_US

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