Pharmacokinetics of levamisole in the red-eared slider turtles (Trachemys scripta elegans)

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dc.contributor.authorCorum, Orhan
dc.contributor.authorDurna Corum, Duygu
dc.contributor.authorAtik, Orkun
dc.contributor.authorAltan, Feray
dc.contributor.authorEr, Ayse
dc.contributor.authorUney, Kamil
dc.date.accessioned2024-04-24T17:11:46Z
dc.date.available2024-04-24T17:11:46Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe pharmacokinetics and bioavailability of levamisole were determined in red-eared slider turtles after single intravenous (IV), intramuscular (IM), and subcutaneous (SC) administration. Nine turtles received levamisole (10 mg/kg) by each route in a three-way crossover design with a washout period of 30 days. Blood samples were collected at time 0 (pretreatment), and at 0.25, 0.5, 1, 1.5, 3, 6, 9, 12, 18, 24, 36, and 48 hr after drug administration. Plasma levamisole concentrations were determined by a high-performance liquid chromatography assay. Data were analyzed by noncompartmental methods. The mean elimination half-life was 5.00, 7.88, and 9.43 hr for IV, IM, and SC routes, respectively. The total clearance and volume of distribution at steady state for the IV route were 0.14 L hr(-1) kg(-1) and 0.81 L/kg, respectively. For the IM and SC routes, the peak plasma concentration was 9.63 and 10.51 mu g/ml, respectively, with 0.5 hr of T-max. The bioavailability was 93.03 and 115.25% for the IM and SC routes, respectively. The IM and SC route of levamisole, which showed the high bioavailability and long t(1/2z), can be recommended as an effective way for treating nematodes in turtles.en_US
dc.identifier.doi10.1111/jvp.12763
dc.identifier.endpage659en_US
dc.identifier.issn0140-7783
dc.identifier.issn1365-2885
dc.identifier.issue6en_US
dc.identifier.pmid30933367
dc.identifier.scopus2-s2.0-85063720229
dc.identifier.scopusqualityQ1
dc.identifier.startpage654en_US
dc.identifier.urihttps://doi.org/10.1111/jvp.12763
dc.identifier.urihttps://hdl.handle.net/11468/17717
dc.identifier.volume42en_US
dc.identifier.wosWOS:000501034000011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal of Veterinary Pharmacology and Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBioavailabilityen_US
dc.subjectLevamisoleen_US
dc.subjectPharmacokineticsen_US
dc.subjectRed-Eared Slider Turtlesen_US
dc.titlePharmacokinetics of levamisole in the red-eared slider turtles (Trachemys scripta elegans)en_US
dc.titlePharmacokinetics of levamisole in the red-eared slider turtles (Trachemys scripta elegans)
dc.typeArticleen_US

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