Lack of any Impact of Histopathology Type on Prognosis in Patients with Early-Stage Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix

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dc.contributor.authorTeke, Fatma
dc.contributor.authorYoney, Adnan
dc.contributor.authorTeke, Memik
dc.contributor.authorInal, Ali
dc.contributor.authorUrakci, Zuhat
dc.contributor.authorEren, Bekir
dc.contributor.authorZincircioglu, Seyit Burhanedtin
dc.date.accessioned2024-04-24T17:28:19Z
dc.date.available2024-04-24T17:28:19Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: The aim of this study was to evaluate the prognosis of patients with stage IA-IIB cervical carcinoma and to investigate a possible correlation of histology with prognosis. Materials and Methods: Two hundred fifty one patients with adenocarcinoma and squamous cell carcinoma (SCC) histology for FIGO (International Federation of Gynecology and Obstetrics) stage IA-IIB uterine cervical carcinomas at the Radiation Oncology Clinic of GH Okmeydani Training and Research Hospital between January 1996 and December 2006 were selected, analyzed retrospectively and evaluated in terms of general characteristics and survival. Disease-free survival (DFS) and overall survival (OS) was calculated using the Kaplan-Meier method and differences were compared with the log-rank test. Multivariate analysis using a Cox-proportional hazards model was used to adjust for prognostic factors and to estimate hazard ratio (HR) with 95% confidence interval (CI). Results: There was no differences between the two tumour types in age, stage, pelvic nodal metastasis, parametrial invasion, surgical margin status, DSI, LVSI, maximal tumor diameter, grade, and treatment modalities. 5-year OS and DFS were 73% and 77%, versus 64% and 69%, for SCC and adenocarcinoma, respectively (p>0.05). Multivariate analysis revealed independent prognostic factors including pelvic nodal metastasis and resection margin status for OS (p=0.008, p=0.002, respectively). Conclusions: Prognosis of FIGO stage IA-IIB cervical cancer patients was found to be the same for those with adenocarcinoma and SCC.en_US
dc.description.sponsorshipDicle University DUBAPen_US
dc.description.sponsorshipWe are grateful to Dicle University DUBAP for their sponsorship about English editing of this manuscript.en_US
dc.identifier.doi10.7314/APJCP.2014.15.6.2815
dc.identifier.endpage2819en_US
dc.identifier.issn1513-7368
dc.identifier.issue6en_US
dc.identifier.pmid24761906
dc.identifier.scopus2-s2.0-84899878015
dc.identifier.scopusqualityQ3
dc.identifier.startpage2815en_US
dc.identifier.urihttps://doi.org/10.7314/APJCP.2014.15.6.2815
dc.identifier.urihttps://hdl.handle.net/11468/20401
dc.identifier.volume15en_US
dc.identifier.wosWOS:000335651700067
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAsian Pacific Organization Cancer Preventionen_US
dc.relation.ispartofAsian Pacific Journal of Cancer Prevention
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdenocarcinomaen_US
dc.subjectSquamous Cell Carcinomaen_US
dc.subjectUterine Cervical Carcinomaen_US
dc.subjectHistologyen_US
dc.subjectPrognosisen_US
dc.titleLack of any Impact of Histopathology Type on Prognosis in Patients with Early-Stage Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervixen_US
dc.titleLack of any Impact of Histopathology Type on Prognosis in Patients with Early-Stage Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix
dc.typeArticleen_US

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