The burden and epidemiology of community-acquired central nervous system infections: a multinational study

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dc.contributor.authorErdem, H.
dc.contributor.authorInan, A.
dc.contributor.authorGuven, E.
dc.contributor.authorHargreaves, S.
dc.contributor.authorLarsen, L.
dc.contributor.authorShehata, G.
dc.contributor.authorPernicova, E.
dc.date.accessioned2024-04-24T16:02:01Z
dc.date.available2024-04-24T16:02:01Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractRisk assessment of central nervous system (CNS) infection patients is of key importance in predicting likely pathogens. However, data are lacking on the epidemiology globally. We performed a multicenter study to understand the burden of community-acquired CNS (CA-CNS) infections between 2012 and 2014. A total of 2583 patients with CA-CNS infections were included from 37 referral centers in 20 countries. Of these, 477 (18.5%) patients survived with sequelae and 227 (8.8%) died, and 1879 (72.7%) patients were discharged with complete cure. The most frequent infecting pathogens in this study were Streptococcus pneumoniae (n = 206, 8%) and Mycobacterium tuberculosis (n = 152, 5.9%). Varicella zoster virus and Listeria were other common pathogens in the elderly. Although staphylococci and Listeria resulted in frequent infections in immunocompromised patients, cryptococci were leading pathogens in human immunodeficiency virus (HIV)-positive individuals. Among the patients with any proven etiology, 96 (8.9%) patients presented with clinical features of a chronic CNS disease. Neurosyphilis, neurobrucellosis, neuroborreliosis, and CNS tuberculosis had a predilection to present chronic courses. Listeria monocytogenes, Staphylococcus aureus, M. tuberculosis, and S. pneumoniae were the most fatal forms, while sequelae were significantly higher for herpes simplex virus type 1 (p < 0.05 for all). Tackling the high burden of CNS infections globally can only be achieved with effective pneumococcal immunization and strategies to eliminate tuberculosis, and more must be done to improve diagnostic capacity.en_US
dc.identifier.doi10.1007/s10096-017-2973-0
dc.identifier.endpage1611en_US
dc.identifier.issn0934-9723
dc.identifier.issn1435-4373
dc.identifier.issue9en_US
dc.identifier.pmid28397100
dc.identifier.scopus2-s2.0-85017266797
dc.identifier.scopusqualityQ1
dc.identifier.startpage1595en_US
dc.identifier.urihttps://doi.org/10.1007/s10096-017-2973-0
dc.identifier.urihttps://hdl.handle.net/11468/14579
dc.identifier.volume36en_US
dc.identifier.wosWOS:000407582200010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal of Clinical Microbiology & Infectious Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleThe burden and epidemiology of community-acquired central nervous system infections: a multinational studyen_US
dc.titleThe burden and epidemiology of community-acquired central nervous system infections: a multinational study
dc.typeArticleen_US

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