Relationship of admission QRS duration and changes in QRS duration with myocardial reperfusion in patients with acute ST segment elevation myocardial infarction (STEMI) treated with fibrinolytic therapy

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dc.contributor.authorKacmaz, Fehmi
dc.contributor.authorMaden, Orhan
dc.contributor.authorCelebi, Savas Aksuyek
dc.contributor.authorUreyen, Cagin
dc.contributor.authorAlyan, Oemer
dc.contributor.authorErbay, Ali Riza
dc.contributor.authorSelcuk, Hatice
dc.date.accessioned2024-04-24T17:15:03Z
dc.date.available2024-04-24T17:15:03Z
dc.date.issued2008
dc.departmentDicle Üniversitesien_US
dc.description34th International Congress on Electrocardiology/48th International Symposium on Vectorcardiography -- JUN 27-30, 2007 -- Istanbul, TURKEYen_US
dc.description.abstractBackground Although ischemia induced QRS complex changes have been described previously, their relationship with impaired reperfusion, which is known to be associated with poor clinical outcomes, is not clear. Methods and Results To investigate the relationship of QRS duration changes with myocardial reperfusion, we studied 165 acute myocardial infarction (MI) patients who were administered fibrinolytic therapy for reperfusion. For each patient, 12-lead electrocardiogram (ECG) with a paper speed of 50mm/s was recorded on admission and repeated at the 60(th) and 90(th) min following fibrinolytic therapy. Based on the myocardial blush grades obtained from a control coronary angiography, patients were divided into reperfusion (grades 2, 3) and impaired reperfusion (grades 0, 1) groups. We detected impaired reperfusion in 74 patients. The patients in the impaired reperfusion group were older, more often diabetic, and had longer pain-to-needle intervals. They also had significantly longer QRS durations at admission compared to reperfusion group patients (91 +/- 11 vs 79 +/- 11ms, p<0.001). Reperfusion group patients showed significantly greater resolution in QRS duration at the 90(th) min post fibrinolysis ECG (18 +/- 5 vs 5 +/- 4ms, p<0.001). In regression analysis, the pain-to-needle time (odds ratio (OR): 0.55, 95% confidence interval (CI) 0.35-0.88, p=0.012), QRS duration on admission (OR: 0.80, 95% CI 0.67-0.97, p=0.021), and change in QRS duration at the post fibrinolysis 90(th) min ECG (OR: 2.43, 95%CI, 1.29-4.60, p=0.006) were determined as independent predictors of adequate reperfusion. Conclusion The present study, for the first time, has shown that admission QRS duration and post fibrinolysis 90(th) min QRS duration changes are related to tissue reperfusion in fibrinolytic administered acute MI patients.en_US
dc.identifier.doi10.1253/circj.72.873
dc.identifier.endpage879en_US
dc.identifier.issn1346-9843
dc.identifier.issn1347-4820
dc.identifier.issue6en_US
dc.identifier.pmid18503209
dc.identifier.scopus2-s2.0-45849112116
dc.identifier.scopusqualityQ1
dc.identifier.startpage873en_US
dc.identifier.urihttps://doi.org/10.1253/circj.72.873
dc.identifier.urihttps://hdl.handle.net/11468/18316
dc.identifier.volume72en_US
dc.identifier.wosWOS:000256136600002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherJapanese Circulation Socen_US
dc.relation.ispartofCirculation Journal
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFibrinolytic Therapyen_US
dc.subjectQrs Durationen_US
dc.subjectReperfusionen_US
dc.titleRelationship of admission QRS duration and changes in QRS duration with myocardial reperfusion in patients with acute ST segment elevation myocardial infarction (STEMI) treated with fibrinolytic therapyen_US
dc.titleRelationship of admission QRS duration and changes in QRS duration with myocardial reperfusion in patients with acute ST segment elevation myocardial infarction (STEMI) treated with fibrinolytic therapy
dc.typeConference Objecten_US

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