Paraoxonase and Arylesterase Activities in Dipper and Non-Dipper Prehypertensive Subjects

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dc.contributor.authorYuksel, Murat
dc.contributor.authorYildiz, Abdulkadir
dc.contributor.authorTekbas, Ebru
dc.contributor.authorGunduz, Ercan
dc.contributor.authorEkinci, Aysun
dc.contributor.authorBilik, Mehmet Zihni
dc.contributor.authorOzaydogdu, Necdet
dc.date.accessioned2024-04-24T17:08:20Z
dc.date.available2024-04-24T17:08:20Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractParaoxonase-1, a high-density lipoprotein linked enzyme complex, was shown to be decreased in several cardiovascular diseases. We aimed to explore whether serum paraoxonase and arylesterase activities differ in dipper and non-dipper prehypertensive subjects compared to healthy controls. Sixty prehypertensive subjects and 30 controls were enrolled. All subjects underwent echocardiographic assessment and 24-hour ambulatory blood pressure monitoring (ABPM). According to the blood pressure (BP) course on ABPM, prehypertensive subjects were categorized into two: non-dipper prehypertensive (NDPH) and dipper prehypertensive (DPH) groups. Serum paraoxonase and arylesterase activities were detected spectrophotometrically. Paraoxonase and arylesterase activities were significantly lower in patients with NDPH compared to both DPH and control groups. Both paraoxonase and arylesterase activities showed significant negative correlations with BP and left ventricular mass index. We have demonstrated that NDPH subjects have lower paraoxonase and arylesterase activities compared to DPH subjects and normotensives. Further prospective studies are needed to clarify the role of paraoxonase and arylesterase activities in the development of overt hypertension in prehypertensive subjects.en_US
dc.identifier.doi10.1097/MD.0000000000000786
dc.identifier.issn0025-7974
dc.identifier.issn1536-5964
dc.identifier.issue17en_US
dc.identifier.pmid25929926
dc.identifier.scopus2-s2.0-84937512273
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1097/MD.0000000000000786
dc.identifier.urihttps://hdl.handle.net/11468/17304
dc.identifier.volume94en_US
dc.identifier.wosWOS:000353799300033
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofMedicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keyword]en_US
dc.titleParaoxonase and Arylesterase Activities in Dipper and Non-Dipper Prehypertensive Subjectsen_US
dc.titleParaoxonase and Arylesterase Activities in Dipper and Non-Dipper Prehypertensive Subjects
dc.typeArticleen_US

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