Effects of dexamethasone on small bowel and kidney oxidative stress and histological alterations in bile duct-ligated rats

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dc.contributor.authorOzturk, Hayrettin
dc.contributor.authorEken, Halil
dc.contributor.authorOzturk, Hulya
dc.contributor.authorBuyukbayram, Huseyin
dc.date.accessioned2024-04-24T16:00:12Z
dc.date.available2024-04-24T16:00:12Z
dc.date.issued2006
dc.departmentDicle Üniversitesien_US
dc.description.abstractOxidative stress plays an important role in the pathogenesis of toxic liver diseases and other hepatic alterations including obstruction of bile flow. It has been shown that the gastrointestinal tract and renal tissue is particularly affected during obstruction of bile flow. In this study, we aimed to evaluate the effects of dexamethasone on small bowel and kidney oxidative stress and histological alterations in bile duct-ligated (BDL) rats. A total of 40 male Sprague-Dawley rats weighing 200-240 g were used in this study. Group 1 (Sham-control, n = 10) rats underwent laparotomy and bile duct was dissected from the surrounding tissue. Group 2 (Dexa-control, n = 10) rats underwent laparotomy and bile duct was dissected from the surrounding tissue. The rats received daily dexamethasone. Group 3 (BDL/Untreated, n = 10) rats were subjected to bile duct ligation and no drug was applied. Group 4 (BDL/Dexa, n = 10) rats received daily dexamethasone by orogastric tube for 14 days after BDL. At the end of the 2-week period, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and malondialdehyde (MDA) were measured and biochemical and histological evaluation were processed. The mean serum bilirubin, liver enzymes, MDA level, and histopathological score significantly decreased and SOD, CAT, and GSH-Px values were significantly increased in group 4 when compared to group 3. Group 3 presented a significant increase in caecal count of E. coli and in aerobe/anaerobe ratio. In group 4, liver was moderately damaged. Ileal biopsies from group 4 demonstrated a significant increase in villus height, total mucosal thickness, and villus density when compared to group 3. Glomerular injury scores (GIS) and arterial injury scores (AIS) in group 3 rats were increased in the juxtamedullary region. In contrast to group 4, tubulo-interstitial lesions were diffuse in group 3 animals. Dexamethasone reduced small bowel and kidney oxidative stress and histological alterations in bile duct-ligated rats with increasing SOD, CAT, and GSH-Px and decreasing MDA levels in rats with obstructed bile duct.en_US
dc.identifier.doi10.1007/s00383-006-1736-2
dc.identifier.endpage718en_US
dc.identifier.issn0179-0358
dc.identifier.issn1437-9813
dc.identifier.issue9en_US
dc.identifier.pmid16896816
dc.identifier.scopus2-s2.0-33748415730
dc.identifier.scopusqualityQ2
dc.identifier.startpage709en_US
dc.identifier.urihttps://doi.org/10.1007/s00383-006-1736-2
dc.identifier.urihttps://hdl.handle.net/11468/14402
dc.identifier.volume22en_US
dc.identifier.wosWOS:000240283300003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Surgery International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBile Duct Ligationen_US
dc.subjectLiveren_US
dc.subjectKidneyen_US
dc.subjectSmall Bowelen_US
dc.subjectOxidative Stressen_US
dc.subjectDexamethasoneen_US
dc.titleEffects of dexamethasone on small bowel and kidney oxidative stress and histological alterations in bile duct-ligated ratsen_US
dc.titleEffects of dexamethasone on small bowel and kidney oxidative stress and histological alterations in bile duct-ligated rats
dc.typeArticleen_US

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