Acute hepatitis: a rare complication of Epstein-Barr virus (EBV) infection

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dc.contributor.authorUlug, Mehmet
dc.contributor.authorCelen, Mustafa Kemal
dc.contributor.authorAyaz, Celal
dc.contributor.authorGeyik, Mehmet Faruk
dc.contributor.authorHosoglu, Salih
dc.date.accessioned2024-04-24T17:21:00Z
dc.date.available2024-04-24T17:21:00Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractInfectious Mononucleosis (IM), a benign lymphoproliferative disease, is the best known clinical syndrome caused by Epstein-Barr Virus (EBV). It usually resolves over a period of weeks or months without sequelae but may occasionally be complicated by a wide variety of neurologic, hematologic, hepatic, respiratory, and psychological complications. In this report we describe a patient with acute hepatitis following EBV-IM in a previously healthy woman. A 26-year-old woman who presented with fever, generalized weakness, nausea, sore throat, yellowing of skin, and a generalized skin rash was admitted to our clinic. Tonsillar enlargement, pharyngeal erythema, palatal petechiae, lymphadenopathy, and jaundice were noted. Significant atypical lymphocytes (> 10%) were seen on the peripheral blood smear. Liver function tests such as ALT: 303 U/L, AST: 172 U/L, ALP: 193 U/L and total bilirubin: 7.3 mg/dl were elevated. Serological tests for EBV infection were consistent with acute infection (EBV virus capsid antigen was reactive with IgM and IgG antibodies). The Monospot test was also positive. On the seventh day, liver function tests and bilirubin had risen to peak level and platelets were decreased. The patient was managed supportively and her critical condition improved and was finally stabilized. Although the prognosis for IM is very favorable, a variety of acute complications may occur.en_US
dc.identifier.doi10.3855/jidc.871
dc.identifier.endpage673en_US
dc.identifier.issn1972-2680
dc.identifier.issue10en_US
dc.identifier.pmid21045362
dc.identifier.scopus2-s2.0-79957786017
dc.identifier.scopusqualityQ2
dc.identifier.startpage668en_US
dc.identifier.urihttps://doi.org/10.3855/jidc.871
dc.identifier.urihttps://hdl.handle.net/11468/19332
dc.identifier.volume4en_US
dc.identifier.wosWOS:000208252700012
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherJ Infection Developing Countriesen_US
dc.relation.ispartofJournal of Infection in Developing Countries
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInfectious Mononucleosisen_US
dc.subjectEpstein-Barr Virusen_US
dc.subjectComplicationen_US
dc.subjectHepatitisen_US
dc.titleAcute hepatitis: a rare complication of Epstein-Barr virus (EBV) infectionen_US
dc.titleAcute hepatitis: a rare complication of Epstein-Barr virus (EBV) infection
dc.typeArticleen_US

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