Chromium histidinate protects against heat stress by modulating the expression of hepatic nuclear transcription factors in quail

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dc.contributor.authorOrhan, C.
dc.contributor.authorAkdemir, F.
dc.contributor.authorSahin, N.
dc.contributor.authorTuzcu, M.
dc.contributor.authorKomorowski, J. R.
dc.contributor.authorHayirli, A.
dc.contributor.authorSahin, K.
dc.date.accessioned2024-04-24T16:24:17Z
dc.date.available2024-04-24T16:24:17Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstract1. This experiment was conducted to evaluate the effects of supplemental chromium histidinate (CrHis) on performance and expressions of hepatic nuclear factors kappaB, an enhancer (NF-B) and an inhibitor (IB) of activated B cells in heat-stressed Japanese quail (Coturnix coturnix japonica). 2. A total of 180, 10-d-old Japanese quail were allocated randomly into 6 groups in a 2x3 factorial arrangement. Birds were reared either at 22 degrees C for 24h/d (thermoneutral, TN) or 34 degrees C for 8h/d (heat stress, HS) for 32d and fed on one of three diets supplemented with 0, 400 or 800 mu g of CrHis per kg of diet. Each group consisted of 10 cages, each containing three quail. Data (performance variables and hepatic NF-B and IB) were analysed using 2-way ANOVA. 3. Heat stress caused reductions in cumulative feed intake (FI) by 5 center dot 7%, weight gain (WG) by 13 center dot 0%, final body weight (FBW) by 10 center dot 3%, carcase weight by 12 center dot 6% and carcase efficiency by 2 center dot 3% and an increase in feed conversion ratio (FCR, feed consumed, g:weight gained, g) by 8 center dot 4%. As supplemental CrHis level increased up to 800 mu g/kg, there were linear increases in cumulative FI (from 602 to 609g), WG (from 134 to 138g), FBW (from 167 to 171g), cold carcase weight (from 110 to 114g) and cold carcase efficiency (from 65 center dot 5 to 66 center dot 4%) and a decrease in FE (from 4 center dot 51 to 4 center dot 42). The environmental temperature by CrHis level interaction effect on performance parameters was insignificant. Hepatic NF-B p65 concentration was higher and hepatic IB concentration was lower in quail exposed to HS than in quail kept at TN temperature. Increasing supplemental CrHis level linearly inhibited hepatic NF-B p65 expression from 134 center dot 4 to 105 center dot 3% and linearly enhanced hepatic IB expression from 73 center dot 4 to 99 center dot 6%. The decrease in hepatic NF-B expression and the increase in hepatic IB expression were more notable in the TN environment than in the HS environment. 4. In conclusion, heat stress depressed performance variables and augmented lipid peroxidation and supplemental CrHis alleviated oxidative stress through modulating expressions of stress-related hepatic nuclear transcription factors (NF-B and IB).en_US
dc.identifier.doi10.1080/00071668.2012.747084
dc.identifier.endpage835en_US
dc.identifier.issn0007-1668
dc.identifier.issn1466-1799
dc.identifier.issue6en_US
dc.identifier.pmid23398428
dc.identifier.scopus2-s2.0-84873921786
dc.identifier.scopusqualityQ1
dc.identifier.startpage828en_US
dc.identifier.urihttps://doi.org/10.1080/00071668.2012.747084
dc.identifier.urihttps://hdl.handle.net/11468/16628
dc.identifier.volume53en_US
dc.identifier.wosWOS:000315678000014
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBritish Poultry Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleChromium histidinate protects against heat stress by modulating the expression of hepatic nuclear transcription factors in quailen_US
dc.titleChromium histidinate protects against heat stress by modulating the expression of hepatic nuclear transcription factors in quail
dc.typeArticleen_US

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