Long-term glucose insulin potassium infusion improves systolic and diastolic function in patients with chronic ischaemic cardiomyopathy

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dc.contributor.authorAlan, S
dc.contributor.authorUlgen, MS
dc.contributor.authorDedeoglu, I
dc.contributor.authorKaya, H
dc.contributor.authorToprak, N
dc.date.accessioned2024-04-24T17:37:37Z
dc.date.available2024-04-24T17:37:37Z
dc.date.issued2003
dc.departmentDicle Üniversitesien_US
dc.description.abstractWe assessed the effects of glucose-insulin-potassium (GIK) using echocardiography, right ventricular catheterisation and myocardial scintigraphy with 99mTc sestamibi in stable patients with ischaemic cardiac dysfunction. Methods: Thirty male patients with stable coronary disease (SCD) and an ejection fraction (EF) <40% were studied for systolic and diastolic function. Glucose 30%, 300 insulin units and KCl 6 g/l were infused at 1 ml/kg per hour for 24 hours. Haemodynamic, echocardiographic and myocardial scintigraphy measurements were recorded at rest on completion of the GIK infusion. Results: A significant increase in EF was observed (32.1 +/- 7.8% and 43.3 +/- 11.6%, p <0.01). A significant prolongation was seen in the diastolic filling periods (365 +/- 52 msec and 428 +/- 70 msec, p <0.05). A significant decrease in pulmonary capillary wedge pressure was measured (22.2 +/- 5.3 and 17.1 +/- 4.3, p <0.01) and a significant decrease in stress score (S S) was observed (13 +/- 7 and 11 +/- 5, p >0.05). Conclusion: Our present work suggests that GIK infusion improves systolic and diastolic function in patients with SCD and an ejection fraction <40%. Further studies are needed to determine whether long-term GIK infusion could be useful for therapeutic strategies in patients with chronic ischaemic coronary diseases.en_US
dc.identifier.endpage422en_US
dc.identifier.issn1424-7860
dc.identifier.issue29-30en_US
dc.identifier.pmid14562192
dc.identifier.scopus2-s2.0-0141736924
dc.identifier.scopusqualityQ1
dc.identifier.startpage419en_US
dc.identifier.urihttps://hdl.handle.net/11468/21074
dc.identifier.volume133en_US
dc.identifier.wosWOS:000185949600003
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherE M H Swiss Medical Publishers Ltden_US
dc.relation.ispartofSwiss Medical Weekly
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschaemic Cardiomyopathyen_US
dc.subjectGik Infusionen_US
dc.titleLong-term glucose insulin potassium infusion improves systolic and diastolic function in patients with chronic ischaemic cardiomyopathyen_US
dc.titleLong-term glucose insulin potassium infusion improves systolic and diastolic function in patients with chronic ischaemic cardiomyopathy
dc.typeArticleen_US

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