Reduced serum paraoxonase-1 levels in vitiligo: further evidence of oxidative stress

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dc.contributor.authorYesilova, Yavuz
dc.contributor.authorTuran, Enver
dc.contributor.authorUcmak, Derya
dc.contributor.authorSelek, Sahabettin
dc.contributor.authorYavuz, Brahim Halil
dc.contributor.authorTanrikulu, Osman
dc.date.accessioned2024-04-24T17:14:46Z
dc.date.available2024-04-24T17:14:46Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractVitiligo is a common disorder that results in depigmented areas of the skin. The pathogenesis of the disease remains unclear, but oxidative stress is one suggested cause. Oxidative stress may be induced by increasing the generation of reactive oxygen species and other free radicals. The generation of reactive oxygen species is known to be associated with a decrease in antioxidant levels. This study examined oxidative stress index in active lesions of generalized vitiligo patients. We analysed serum levels of paraoxonase 1, arylesterase, catalase, ceruloplasmin, total antioxidant capacity, and oxidative stress index in patients with active lesions of generalized vitiligo, as well as in matched, healthy controls. Serum oxidants and oxidative stress indexes were higher, and serum antioxidants were lower, in vitiligo patients compared with healthy controls. Our findings suggest that oxidative stress may play an important role in the pathogenesis of vitiligo. Paraoxonase 1 can be used as an indicator in determining oxidative stress existent in the pathogenesis of vitiligo diseases.en_US
dc.identifier.doi10.1179/1351000212Y.0000000025
dc.identifier.endpage218en_US
dc.identifier.issn1351-0002
dc.identifier.issn1743-2928
dc.identifier.issue5en_US
dc.identifier.pmid23068968
dc.identifier.scopus2-s2.0-84867689682
dc.identifier.scopusqualityQ2
dc.identifier.startpage214en_US
dc.identifier.urihttps://doi.org/10.1179/1351000212Y.0000000025
dc.identifier.urihttps://hdl.handle.net/11468/18188
dc.identifier.volume17en_US
dc.identifier.wosWOS:000309971800006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRedox Report
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectVitiligoen_US
dc.subjectParaoxonase 1en_US
dc.subjectOxidative Stress Indexen_US
dc.titleReduced serum paraoxonase-1 levels in vitiligo: further evidence of oxidative stressen_US
dc.titleReduced serum paraoxonase-1 levels in vitiligo: further evidence of oxidative stress
dc.typeArticleen_US

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