EFFECTS OF ETHYL PYRUVATE ON TESTICULAR DAMAGE IN RATS WITH STREPTOZOTOCIN-INDUCED DIABETES

Basit Öğe Kaydı
dc.contributor.authorAkkoc, H.
dc.contributor.authorKelle, I.
dc.contributor.authorTunik, S.
dc.contributor.authorErdinc, M.
dc.contributor.authorErdinc, L.
dc.contributor.authorNergiz, Y.
dc.date.accessioned2024-04-24T17:24:20Z
dc.date.available2024-04-24T17:24:20Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractDiabetes mellitus is associated with impairment of testicular functions. Aim. The present study aimed to investigate the effects of ethyl pyruvate (EP) on the testicular tissue damage in rats with streptozotocin (STZ)-induced diabetes. Subjects and methods. Thirty-two Wistar albino male rats were assigned into four equal groups as follows: (1) control group (n:8); (2) EP-treated non-diabetic group (n:8); (3) diabetic group (n:8); and (4) EP-treated diabetic group (n:8). Rats with STZ-induced diabetes were kept alive for 14 weeks. After that, the EP solution was administered intraperitoneally to the rats in the EP-treated non-diabetic and diabetic groups at the dose of 50 mg/kg twice daily for 14 clays. At the end of this period, the left testes were removed from the rats for malondialdehyde (MDA) analysis, and the right testes were removed for histological examination. Results. As compared with the control group, the diabetic group had elevated MDA levels (210.9 +/- 12.7) and increased thickness of the basement membrane of the seminiferous tubules (3.01 +/- 0.16), but decreased tubular diameter (159 +/- 9.0) and Johnsen's score (5.31 +/- 0.1). In the EP-treated diabetic group, diabetes-induced impairment was significantly improved. Conclusion. These findings indicate that EP shows protective effects against diabetes-induced testicular dysfunction.en_US
dc.identifier.doi10.4183/aeb.2012.35
dc.identifier.endpage45en_US
dc.identifier.issn1841-0987
dc.identifier.issn1843-066X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84861017462
dc.identifier.scopusqualityQ4
dc.identifier.startpage35en_US
dc.identifier.urihttps://doi.org/10.4183/aeb.2012.35
dc.identifier.urihttps://hdl.handle.net/11468/19612
dc.identifier.volume8en_US
dc.identifier.wosWOS:000302189400004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherEditura Acad Romaneen_US
dc.relation.ispartofActa Endocrinologica-Bucharest
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetes-Induced Testicular Damageen_US
dc.subjectEthyl Pyruvateen_US
dc.subjectStreptozotocinen_US
dc.subjectMalondialdehydeen_US
dc.subjectHistopathologyen_US
dc.titleEFFECTS OF ETHYL PYRUVATE ON TESTICULAR DAMAGE IN RATS WITH STREPTOZOTOCIN-INDUCED DIABETESen_US
dc.titleEFFECTS OF ETHYL PYRUVATE ON TESTICULAR DAMAGE IN RATS WITH STREPTOZOTOCIN-INDUCED DIABETES
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu