EFFECTS OF ETHYL PYRUVATE ON TESTICULAR DAMAGE IN RATS WITH STREPTOZOTOCIN-INDUCED DIABETES
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Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Editura Acad Romane
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Diabetes mellitus is associated with impairment of testicular functions. Aim. The present study aimed to investigate the effects of ethyl pyruvate (EP) on the testicular tissue damage in rats with streptozotocin (STZ)-induced diabetes. Subjects and methods. Thirty-two Wistar albino male rats were assigned into four equal groups as follows: (1) control group (n:8); (2) EP-treated non-diabetic group (n:8); (3) diabetic group (n:8); and (4) EP-treated diabetic group (n:8). Rats with STZ-induced diabetes were kept alive for 14 weeks. After that, the EP solution was administered intraperitoneally to the rats in the EP-treated non-diabetic and diabetic groups at the dose of 50 mg/kg twice daily for 14 clays. At the end of this period, the left testes were removed from the rats for malondialdehyde (MDA) analysis, and the right testes were removed for histological examination. Results. As compared with the control group, the diabetic group had elevated MDA levels (210.9 +/- 12.7) and increased thickness of the basement membrane of the seminiferous tubules (3.01 +/- 0.16), but decreased tubular diameter (159 +/- 9.0) and Johnsen's score (5.31 +/- 0.1). In the EP-treated diabetic group, diabetes-induced impairment was significantly improved. Conclusion. These findings indicate that EP shows protective effects against diabetes-induced testicular dysfunction.
Açıklama
Anahtar Kelimeler
Diabetes-Induced Testicular Damage, Ethyl Pyruvate, Streptozotocin, Malondialdehyde, Histopathology
Kaynak
Acta Endocrinologica-Bucharest
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
8
Sayı
1
