Evaluation of iodine and selenium level and thyroid functions in patients with cystic fibrosis

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dc.authoridARICA, ENES/0000-0002-8663-4826
dc.authoridtas, funda feryal/0000-0003-2438-0602
dc.contributor.authorUnal, Edip
dc.contributor.authorArica, Enes
dc.contributor.authorTas, Funda Feryal
dc.contributor.authorKolbasi, Baris
dc.contributor.authorBeyazit, Nurcan
dc.contributor.authorKaplan, Ibrahim
dc.contributor.authorSavas, Suat
dc.date.accessioned2025-02-22T14:08:48Z
dc.date.available2025-02-22T14:08:48Z
dc.date.issued2025
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjectives There is limited research on thyroid function in pediatric patients with cystic fibrosis (pwCF). This study aimed to determine the frequency of thyroid dysfunction in children and adolescents with CF and to evaluate iodine deficiency and selenium status in pwCF.Methods Sixty-two CF patients and 62 control subjects were evaluated. The anthropometric measurements, nutritional status, FEV1(Forced-expiratory-volume in 1 s) percentage, thyroid function tests (TSH, FT4, FT3), urinary iodine and selenium levels, hospitalization status in the last six months, antibiotic usage, and colonization status with staphylococcus or pseudomonas were assessed for the cases.Results The mean age of the patient group was 10.84 +/- 4.04 years. All CF patients were receiving multivitamin supplementation. Malnutrition was present in 50 % of patients, bacterial colonization in 29 %, FEV1 decrease in 38.5 %, subclinical hypothyroidism (SH) in 12.9 %, iodine deficiency in 87 % and exocrine pancreatic insufficiency in 100 %. T3 levels were found to be higher in pwCF. No significant difference was found between malnutrition and FEV1 and urinary iodine and selenium levels. Compared to the control group, pwCF had lower urinary iodine levels.Conclusions To the best of our knowledge, our study is one of the few in the literature to investigate urinary selenium levels alongside iodine in PwCF. Further research is needed to clarify and interpret elevated urinary selenium levels in this context. It was shown that iodine deficiency and the rate of SH were relatively high in pwCF. However, it was still thought that correcting iodine deficiency in these patients could improve thyroid dysfunction associated with CF.en_US
dc.identifier.doi10.1515/jpem-2024-0566
dc.identifier.issn0334-018X
dc.identifier.issn2191-0251
dc.identifier.pmid39817663en_US
dc.identifier.scopus2-s2.0-85215860620en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1515/jpem-2024-0566
dc.identifier.urihttps://hdl.handle.net/11468/29646
dc.identifier.wosWOS:001396804100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofJournal of Pediatric Endocrinology & Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectcystic fibrosisen_US
dc.subjectiodineen_US
dc.subjectseleniumen_US
dc.subjectthyroid dysfunctionen_US
dc.titleEvaluation of iodine and selenium level and thyroid functions in patients with cystic fibrosisen_US
dc.typeArticleen_US

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