Extended-spectrum beta-lactamases in ceftazidime-resistant Escherichia coli and Klebsiella pneumoniae isolates in Turkish hospitals

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dc.contributor.authorHoşoǧlu, Salih
dc.contributor.authorGündeş, Sibel G.
dc.contributor.authorKolaylı, Fetiye
dc.contributor.authorKaradenizli, Aynur Y.
dc.contributor.authorDemirdaǧ, Kutbettin
dc.contributor.authorGünaydın, Murat
dc.contributor.authorAltındiş, Mustafa
dc.date.accessioned2024-04-24T17:58:19Z
dc.date.available2024-04-24T17:58:19Z
dc.date.issued2007
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Ana Bilim Dalıen_US
dc.description.abstractPurpose: To study the prevalence of TEM-, SHV- and GES-type ?-lactamases among Escherichia coli and Klebsiella pneumoniae strains having ceftazidime MICs higher than 2 mg/L. Methods: A total of 63 E. coli and 41 K. pneumoniae isolated from five different university hospitals were studied for the existence of TEM-, SHV- and GES-type ?-lactamases. Susceptibility tests were carried out according to the criteria of National Committee for Clinical Laboratory Standards. MICs were obtained by agar dilution method. Existence of extended-spectrum ?-lactamases (ESBLs) were assessed by double-disc synergy test (DDST). Existence of the above-mentioned ?-lactamase genes were studied both by PCR with specific oligonucleotide primers and isoelectric focusing methods. Results: None of the isolates were carbapenem-resistant. DDSTs were positive in 50 (79.3%) and 33 (80.5%) of E. coli and K. pneumoniae , respectively. TEM gene was detected in 41 (65.1%) and 19 (46.3%), whereas SHV gene in 18 (28.6%) and 20 (48.8%) of E. coli and K. pneumoniae strains, respectively. GES genes were not detected. Conclusions: TEM and SHV genes are highly prevalent among ESBL-producing E. coli and K. pneumoniae , whereas GES-type ESBLs are absent and found not to be responsible of ceftazidime resistance in Turkish hospitals.en_US
dc.identifier.citationHoşoǧlu, S., Gündeş, S. G., Kolaylı, F., Karadenizli, A. Y., Demirdaǧ, K., Günaydın, M. ve diğerleri. (2007). Extended-spectrum beta-lactamases in ceftazidime-resistant Escherichia coli and Klebsiella pneumoniae isolates in Turkish hospitals. Indian Journal of Medical Microbiology, 25(4), 346-350.
dc.identifier.doi10.4103/0255-0857.37336
dc.identifier.endpage350en_US
dc.identifier.issn0255-0857
dc.identifier.issue4en_US
dc.identifier.pmid18087082
dc.identifier.scopus2-s2.0-37549009519
dc.identifier.scopusqualityQ2
dc.identifier.startpage346en_US
dc.identifier.urihttps://doi.org/10.4103/0255-0857.37336
dc.identifier.urihttps://hdl.handle.net/11468/23829
dc.identifier.volume25en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherMedknow Publications and Media Pvt. Ltden_US
dc.relation.ispartofIndian Journal of Medical Microbiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCeftazidime-Resistanten_US
dc.subjectE. Colien_US
dc.subjectEsblen_US
dc.subjectGesen_US
dc.subjectKlebsiellaen_US
dc.subjectShven_US
dc.subjectTemen_US
dc.titleExtended-spectrum beta-lactamases in ceftazidime-resistant Escherichia coli and Klebsiella pneumoniae isolates in Turkish hospitalsen_US
dc.titleExtended-spectrum beta-lactamases in ceftazidime-resistant Escherichia coli and Klebsiella pneumoniae isolates in Turkish hospitals
dc.typeArticleen_US

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