Evaluation of oxidative stress in children with congenital heart defects

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dc.contributor.authorPirinccioglu, Ayfer Gozu
dc.contributor.authorAlyan, Omer
dc.contributor.authorKizil, Goksel
dc.contributor.authorKangin, Murat
dc.contributor.authorBeyazit, Nurcan
dc.date.accessioned2024-04-24T17:11:33Z
dc.date.available2024-04-24T17:11:33Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: A significant cause of death and chronic illness in childhood is caused by cardiovascular diseases, including congenital heart disease (CHD). This study aims to investigate the oxidative stress status and to establish its association with CHD in children. Methods: The study involves measurements of malondialdehyde (MDA), protein carbonyl (PCO), total anti-oxidant capacity, high-sensitive C-reactive protein (hs-CRP), fibrinogen and cytokine (interleukin [IL-6] and tumor necrosis factor-alpha) levels in 43 children with CHD and 30 healthy age-matched children. Results: MDA, PCO, hs-CRP, fibrinogen, IL-6 and tumor necrosis factor-alpha were significantly elevated while total anti-oxidant capacity was significantly declined in patients compared with the controls. MDA was positively correlated with PCO, hs-CRP, Qp/Qs and systolic pulmonary artery pressure. PCO was positively correlated with hs-CRP, fibrinogen, IL-6 and systolic pulmonary artery pressure. Conclusion: Oxidative stress and its association with other markers in children with CHD was established. To the best of our knowledge, this is the first time that PCO has been used as a biomarker in CHD and it may be employed as a new diagnostic biomarker in CHD and in the assessment of its severity.en_US
dc.identifier.doi10.1111/j.1442-200X.2011.03478.x
dc.identifier.endpage98en_US
dc.identifier.issn1328-8067
dc.identifier.issn1442-200X
dc.identifier.issue1en_US
dc.identifier.pmid21917064
dc.identifier.scopus2-s2.0-84857204198
dc.identifier.scopusqualityQ3
dc.identifier.startpage94en_US
dc.identifier.urihttps://doi.org/10.1111/j.1442-200X.2011.03478.x
dc.identifier.urihttps://hdl.handle.net/11468/17599
dc.identifier.volume54en_US
dc.identifier.wosWOS:000300671100018
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatrics International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute-Phase Reactantsen_US
dc.subjectChildrenen_US
dc.subjectCongenital Heart Diseaseen_US
dc.subjectCytokinesen_US
dc.subjectOxidative Stressen_US
dc.titleEvaluation of oxidative stress in children with congenital heart defectsen_US
dc.titleEvaluation of oxidative stress in children with congenital heart defects
dc.typeArticleen_US

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