Serum cytokine and pro-brain natriuretic peptide (BNP) levels in patients with migraine

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dc.contributor.authorUzar, E.
dc.contributor.authorEvliyaoglu, O.
dc.contributor.authorYucel, Y.
dc.contributor.authorCevik, M. Ugur
dc.contributor.authorAcar, A.
dc.contributor.authorGuzel, I.
dc.contributor.authorIslamoglu, Y.
dc.date.accessioned2024-04-24T17:38:02Z
dc.date.available2024-04-24T17:38:02Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Although migraine has been related with an increased risk for ischemic stroke and cardiovascular events, there is insufficient data for role of pro-brain natriuretic peptide (pro-BNP) in migraine. In present case-control study, serum levels of pro-inflammatory (TNF-alpha, IL-1 beta and IL-6) and anti-inflammatory cytokines (IL-2, and IL-10) of migraine patients were investigated to determine the role of cytokines and pro-BNP in migraine. Patients and Methods: Sixty-four consecutive newly diagnosed migraine patients and 34 healthy controls were enrolled. Serum TNF-alpha, IL1 beta, IL-2, IL-6, IL-10 and pro-BNP levels were measured by using a chemiluminescence assay. Results: Migraine patients had significantly higher concentrations of IL-1 beta and IL-6 compared with the healthy controls (for IL-1 beta; 5.73 +/- 1.44 vs. 4.90 +/- 1.40 pg/mL, respectively, p = 0.006; for IL-6; 3.1 +/- 1.44 vs. 2.40 +/- 0.22 pg/mL, respectively, p = 0.007). The mean IL-10 levels were found to be significantly lower in migraine patients (3.38 +/- 2.93 pg/mL) than controls (6.76 +/- 1.48 pg/mL) (p = 0.007). There were no differences in TNF-alpha (27.2 +/- 48.1 vs. 15.4 +/- 0.7) and IL-2 (1017 +/- 661 vs. 1153 +/- 228) levels between patients with migraine and healthy controls. Migraine patients had higher concentrations of pro-BNP compared with healthy controls (27.0 +/- 28.0 versus 13.2 +/- 8.6, p = 0.006). Conclusions: Migraine patients have higher serum IL-1 beta and IL-6 levels, and lower IL-10 levels than healthy subjects. These findings support that cytokines may be related to neurogenic inflammation in the pathogenesis of migraine. Also, increased pro-BNP may indicate to preclinical cardiac involvement in patients with migraine.en_US
dc.identifier.endpage1116en_US
dc.identifier.issn1128-3602
dc.identifier.issue10en_US
dc.identifier.pmid22165670
dc.identifier.scopus2-s2.0-82455174249
dc.identifier.scopusqualityQ2
dc.identifier.startpage1111en_US
dc.identifier.urihttps://hdl.handle.net/11468/21300
dc.identifier.volume15en_US
dc.identifier.wosWOS:000296917400001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMigraineen_US
dc.subjectPro-Bnpen_US
dc.subjectCytokineen_US
dc.subjectPathogenesisen_US
dc.subjectBiomarkeren_US
dc.titleSerum cytokine and pro-brain natriuretic peptide (BNP) levels in patients with migraineen_US
dc.titleSerum cytokine and pro-brain natriuretic peptide (BNP) levels in patients with migraine
dc.typeArticleen_US

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