Immunological Parameters in Migraine Patients

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dc.contributor.authorTasdemir, Nebahat
dc.contributor.authorUlug, Nuray Can
dc.contributor.authorDogan, Bahar Burtan
dc.date.accessioned2024-04-24T17:37:31Z
dc.date.available2024-04-24T17:37:31Z
dc.date.issued2009
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: In this study, we aimed to investigate by measuring differences between the levels of plasma cytokines interleukin-1 beta (IL-1 beta), IL-2 receptor, IL-6, IL-8, IL-10, turnout necrotizing factor alpha (TNF-alpha), compleman 3 (Q) and 4 (C4); immunoglobulins G (IgG), IgA, IgM, IgE during migraine attacks and headache-free periods. Material and Methods: Seventy-two patients and 41 age and sex matched healthy people were enrolled in the study. The diagnosis was made according to the International Classification of Headache Disorders (ICHD-II) criteria. Thirty patients out of 72 were in a migraine status while 42 were headache-free. The plasma levels of the cytokines such as IL-10, IL-2 receptor, IL-6, IL-8, IL-10, TNF-alpha, complements (C3, C4) and immunoglobulins were measured in all patients and the controls. Results: The level of TNF-alpha was higher during the attack and the headache-free period in migraine patients than in the healthy control group. The level of C3 was higher during a headache-free period than in the healthy control group. There were significant differences between groups regarding IL-1 beta, IL-6, IL-10 and IgG levels. Conclusion: Immunologic alterations and activity of proinflammatory markers were present during the migraine attack and headache free period in migraine patients.en_US
dc.identifier.endpage1629en_US
dc.identifier.issn1300-0292
dc.identifier.issn2146-9040
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-76749102501
dc.identifier.scopusqualityQ4
dc.identifier.startpage1623en_US
dc.identifier.urihttps://hdl.handle.net/11468/20986
dc.identifier.volume29en_US
dc.identifier.wosWOS:000273915500039
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.publisherOrtadogu Ad Pres & Publ Coen_US
dc.relation.ispartofTurkiye Klinikleri Tip Bilimleri Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMigraine Disordersen_US
dc.subjectCytokinesen_US
dc.subjectImmunoglobulinsen_US
dc.titleImmunological Parameters in Migraine Patientsen_US
dc.titleImmunological Parameters in Migraine Patients
dc.typeArticleen_US

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