Immunological Parameters in Migraine Patients

[ X ]

Tarih

2009

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Ortadogu Ad Pres & Publ Co

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Objective: In this study, we aimed to investigate by measuring differences between the levels of plasma cytokines interleukin-1 beta (IL-1 beta), IL-2 receptor, IL-6, IL-8, IL-10, turnout necrotizing factor alpha (TNF-alpha), compleman 3 (Q) and 4 (C4); immunoglobulins G (IgG), IgA, IgM, IgE during migraine attacks and headache-free periods. Material and Methods: Seventy-two patients and 41 age and sex matched healthy people were enrolled in the study. The diagnosis was made according to the International Classification of Headache Disorders (ICHD-II) criteria. Thirty patients out of 72 were in a migraine status while 42 were headache-free. The plasma levels of the cytokines such as IL-10, IL-2 receptor, IL-6, IL-8, IL-10, TNF-alpha, complements (C3, C4) and immunoglobulins were measured in all patients and the controls. Results: The level of TNF-alpha was higher during the attack and the headache-free period in migraine patients than in the healthy control group. The level of C3 was higher during a headache-free period than in the healthy control group. There were significant differences between groups regarding IL-1 beta, IL-6, IL-10 and IgG levels. Conclusion: Immunologic alterations and activity of proinflammatory markers were present during the migraine attack and headache free period in migraine patients.

Açıklama

Anahtar Kelimeler

Migraine Disorders, Cytokines, Immunoglobulins

Kaynak

Turkiye Klinikleri Tip Bilimleri Dergisi

WoS Q Değeri

Q4

Scopus Q Değeri

Q4

Cilt

29

Sayı

6

Künye