Histopathological Evaluation of the Curative Effects of EDTA on Lymnaea stagnalis Exposed to Subacute Cadmium

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dc.contributor.authorOtludil, Birguel
dc.contributor.authorKarakas, Serpil Burcun
dc.date.accessioned2025-02-22T14:09:08Z
dc.date.available2025-02-22T14:09:08Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractWe investigated the therapeutic effects of EDTA application for 14 and 28 days on cadmium (Cd) induced pond snail Lymnaea stagnalis (Linnaeus, 1758). The sublethal concentration of cadmium (63.4 mg/l Cd) caused tissue damages to the snail after an exposure for 28 days. In the groups treated with EDTA, the concentration of Cd in the foot, mantle and hepatopancreas tissues showed significantly decreased during the recovery period. The curative effects of EDTA on Cd-induced damage were assessed using a scoring system. Cadmium exposure led to histopathological changes including increased mucositis, pigment and protein cells, foot epithelium desquamation, muscle fibril damage, connective tissue cell atrophy, and increased lipid vacuoles in the mantle and hepatopancreas. However, these changes were less severe in snails treated with EDTA (2.00 mL/L for 28 day), indicating that EDTA reduces their susceptibility to heavy metal toxicity.en_US
dc.description.sponsorshipDicle niversitesi [07-02-19]; University of Dicle (DUBAP)en_US
dc.description.sponsorshipThe authors would like to extend grateful thanks to Professor Erhan Unlu (University of Dicle) his expert advice and comments. This study was funded by the University of Dicle (DUBAP; 07-02-19), providing financial support for the research.en_US
dc.identifier.doi10.1007/s00128-024-03893-y
dc.identifier.issn0007-4861
dc.identifier.issn1432-0800
dc.identifier.issue6en_US
dc.identifier.pmid38822851en_US
dc.identifier.scopus2-s2.0-85195009035en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1007/s00128-024-03893-y
dc.identifier.urihttps://hdl.handle.net/11468/29805
dc.identifier.volume112en_US
dc.identifier.wosWOS:001236839100004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofBulletin of Environmental Contamination and Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectHistopathologyen_US
dc.subjectCadmiumen_US
dc.subjectEDTAen_US
dc.subjectProtectiveen_US
dc.subjectGastropodaen_US
dc.titleHistopathological Evaluation of the Curative Effects of EDTA on Lymnaea stagnalis Exposed to Subacute Cadmiumen_US
dc.typeArticleen_US

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