Impact of the arginine silicate inositol complex on bone metabolism in broiler chickens with tibial dyschondroplasia caused by manganese deficiency

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dc.contributor.authorSahin, E.
dc.contributor.authorIpcak, H. H.
dc.contributor.authorOrhan, C.
dc.contributor.authorDenli, M.
dc.contributor.authorErten, F.
dc.contributor.authorOzercan, I. H.
dc.contributor.authorBalci, T. A.
dc.date.accessioned2024-04-24T16:24:17Z
dc.date.available2024-04-24T16:24:17Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstract1. Tibial dyschondroplasia (TD) is a skeletal disorder in broilers that has financial implications, necessitating dietary modifications to reduce the prevalence of this disease. This study explored how arginine silicate inositol complex (ASI) supplementation affected tibial growth plate (TGP) and overall bone health in broilers with manganese (Mn) deficiency-induced TD. 2. A total of 240 broiler chicks were divided into four groups, each consisting of 60 birds (15 replicates of four broilers each) as follows: i) Control, with 60 mg Mn per kg of diet; ii) ASI, with 60 mg Mn and 1 g ASI per kg of diet; iii) TD, with 22 mg Mn per kg of diet, and iv) TD+ASI, with 22 mg Mn and 1 g ASI per kg of diet. 3. It was found that ASI supplementation increased tibial bone length in Mn-deficient TD broilers (p = 0.007). There was no Mn x ASI interaction for other bone morphometry variables (p > 0.05). However, both tibial bone mineral content and density were affected by Mn and ASI (p < 0.05). With ASI supplementation, serum bone-specific alkaline phosphatase and osteocalcin levels were elevated in the TD+ASI group compared to the TD group (p < 0.001). In the TD group, osteoprotegerin (OPG) levels in the TGP decreased compared to the control groups (p < 0.001). 4. In contrast, ASI supplementation in the TD broilers counteracted the decrease in OPG compared to TD broilers without ASI supplementation (p < 0.001). The Mn level and ASI supplementation significantly influenced the OPG/receptor activator of the nuclear factor-kappa B ligand ratio (p < 0.001). 5. In conclusion, the results demonstrated that inclusion of ASI in broiler diets could enhance bone formation variables by controlling OPG levels in the TGP, potentially serving as an effective method to decrease the occurrence of TD.en_US
dc.description.sponsorshipTurkish Academy of Science (Turkiye Bilimler Akademisi)en_US
dc.description.sponsorshipThis project was partly funded by Turkish Academy of Science (Turkiye Bilimler Akademisi). The funding body was not involved in the project design, collection, analysis, interpretation of data, writing or the decision to submit it for publication.en_US
dc.identifier.doi10.1080/00071668.2024.2332724
dc.identifier.issn0007-1668
dc.identifier.issn1466-1799
dc.identifier.pmid38598261
dc.identifier.scopus2-s2.0-85190407493
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1080/00071668.2024.2332724
dc.identifier.urihttps://hdl.handle.net/11468/16631
dc.identifier.wosWOS:001200465600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBritish Poultry Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBroileren_US
dc.subjectTibial Dyschondroplasiaen_US
dc.subjectArginine Silicate Inositol Complexen_US
dc.subjectBone Qualityen_US
dc.subjectMolecular Mechanismen_US
dc.titleImpact of the arginine silicate inositol complex on bone metabolism in broiler chickens with tibial dyschondroplasia caused by manganese deficiencyen_US
dc.titleImpact of the arginine silicate inositol complex on bone metabolism in broiler chickens with tibial dyschondroplasia caused by manganese deficiency
dc.typeArticleen_US

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