Macroscopic portal vein thrombosis in HCC patients

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dc.authorid0000-0001-9745-8875en_US
dc.authorid0000-0002-6111-5077en_US
dc.authorid0000-0003-2137-7934en_US
dc.contributor.authorAkkız, Hikmet
dc.contributor.authorCarr, Brian Irving
dc.contributor.authorKuran, Sedef
dc.contributor.authorKaraoğullarından, Ümit
dc.contributor.authorÜsküdar, Oǧuz
dc.contributor.authorTokmak, Salih
dc.contributor.authorYalçın, Kendal
dc.contributor.authorEkinci, Nazım
dc.date.accessioned2024-01-29T06:18:05Z
dc.date.available2024-01-29T06:18:05Z
dc.date.issued2018en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.description.abstractMacroscopic portal vein invasion (PVT) by hepatocellular carcinoma (HCC) in the liver is one of the most important negative prognostic factors for HCC patients. The characteristics of a large cohort of such patients were examined. We found that the percent of patients with PVT significantly increased with increasing maximum tumor diameter (MTD), from 13.7% with tumors of MTD [removed]10cm. There were similar numbers of HCC patients with very large tumors with and without PVT. Thus, MTD alone was insufficient to explain the presence of PVT, as were high AFP levels, since less than 50% of high AFP patients had PVT. However, the percent of patients with PVT was also found to significantly increase with increasing blood alpha-fetoprotein (AFP) levels and tumor multifocality. A logistic regression model that included these 3 factors together showed an odds ratio of 17.9 for the combination of MTD>5.0cm plus tumor multifocality plus elevated AFP, compared to low levels of these 3 parameters. The presence or absence of macroscopic PVT may therefore represent different HCC aggressiveness phenotypes, as judged by a significant increase in tumor multifocality and AFP levels in the PVT positive patients. Factors in addition to MTD and AFP must also contribute to PVT development.en_US
dc.identifier.citationAkkız, H., Carr, B. I., Kuran, S., Karaoğullarından, Ü., Üsküdar, O., Tokmak, S. ve diğerleri. (2018). Macroscopic portal vein thrombosis in HCC patients. Canadian Journal of Gastroenterology and Hepatology, 2018, 3120185.en_US
dc.identifier.doi10.1155/2018/3120185en_US
dc.identifier.endpage9en_US
dc.identifier.issn2291-2789
dc.identifier.pmid30009156en_US
dc.identifier.scopus2-s2.0-85049358746en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.hindawi.com/journals/cjgh/2018/3120185/
dc.identifier.urihttps://hdl.handle.net/11468/13287
dc.identifier.volume2018en_US
dc.identifier.wosWOS:000436297600001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYalçın, Kendal
dc.institutionauthorEkinci, Nazım
dc.language.isoenen_US
dc.publisherHindawi Limiteden_US
dc.relation.ispartofCanadian Journal of Gastroenterology and Hepatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHCC patientsen_US
dc.subjectThrombosisen_US
dc.titleMacroscopic portal vein thrombosis in HCC patientsen_US
dc.typeArticleen_US

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