The relationship of serum SCUBE-1,-2 and-3 levels with clinical findings and ultrasonographic skin thickness in systemic sclerosis patients

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dc.contributor.authorGunduz, Ibrahim
dc.contributor.authorBatmaz, Ibrahim
dc.contributor.authorBozan, Turgut
dc.contributor.authorEkinci, Aysun
dc.contributor.authorCevik, Remzi
dc.date.accessioned2024-04-24T17:11:24Z
dc.date.available2024-04-24T17:11:24Z
dc.date.issued2020
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim This study aimed to investigate the relationship between the level of serum signal peptide-CUB-EGF domain-containing protein (SCUBE)-1, SCUBE-2 and SCUBE-3 and clinical findings and ultrasonographic skin thickness in systemic sclerosis (SSc). Material and Methods Thirty patients who met the American College of Rheumatology/European League against Rheumatism 2013 SSc classification criteria and 44 healthy volunteers who were compatible with the patient group in terms of age and gender were included in the study. Serum SCUBE levels were measured by enzyme-linked immunosorbent assay. Ultrasonographic skin thickness measurements were simultaneously performed. Results No significant difference was found between the serum SCUBE levels of SSc patients and serum SCUBE levels of the control group. A negative correlation was detected between serum SCUBE-1 level and forced expiratory volume in 1 second (FEV1). While a positive correlation was detected between serum SCUBE-2 level and the Duruoz Hand Index and serum C4 level, a negative correlation was determined with the forced vital capacity (FVC) value. A negative correlation was determined between serum SCUBE-3 level and echocardiographic pulmonary artery pressure (PAP). A correlation could not be determined between serum SCUBE levels and ultrasonographic skin thickness. However, a positive correlation was observed between ultrasonographic skin thickness and the modified Rodnan skin score. Conclusion In this study, a correlation was observed between serum SCUBE levels and some clinical and laboratory parameters (FEV1, FVC, PAP, C4, and Duruoz Hand Index) in SSc patients. New clinical studies are needed to better understand the contribution of these molecules in the progression and pathogenesis of SSc.en_US
dc.identifier.doi10.1111/1756-185X.13798
dc.identifier.endpage531en_US
dc.identifier.issn1756-1841
dc.identifier.issn1756-185X
dc.identifier.issue4en_US
dc.identifier.pmid31991528
dc.identifier.scopus2-s2.0-85078731372
dc.identifier.scopusqualityQ3
dc.identifier.startpage526en_US
dc.identifier.urihttps://doi.org/10.1111/1756-185X.13798
dc.identifier.urihttps://hdl.handle.net/11468/17480
dc.identifier.volume23en_US
dc.identifier.wosWOS:000525412900008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal of Rheumatic Diseases
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectScubeen_US
dc.subjectSkin Thicknessen_US
dc.subjectSystemic Sclerosisen_US
dc.subjectUltrasonographyen_US
dc.titleThe relationship of serum SCUBE-1,-2 and-3 levels with clinical findings and ultrasonographic skin thickness in systemic sclerosis patientsen_US
dc.titleThe relationship of serum SCUBE-1,-2 and-3 levels with clinical findings and ultrasonographic skin thickness in systemic sclerosis patients
dc.typeArticleen_US

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