Investigation of the electrochemical properties of edoxaban using glassy carbon and boron-doped diamond electrodes and development of an eco-friendly and cost effective voltammetric method for its determination

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dc.authorid0000-0001-5792-419Xen_US
dc.contributor.authorKılıç, Abdulkadir
dc.contributor.authorAslan, Mehmet
dc.contributor.authorLevent, Abdulkadir
dc.date.accessioned2024-01-15T11:45:56Z
dc.date.available2024-01-15T11:45:56Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Fen Fakültesi, Kimya Bölümüen_US
dc.description.abstractIn this study, the highly risky drug Edoxaban (EDX), which can threaten life and cause bleeding, was electro analytically evaluated. The electrochemical behavior of EDX was investigated using glassy carbon electrode (GCE) and boron-doped diamond electrode (BDDE). In this study, for the first time, a simple, rapid, sensitive, and selective voltammetric technique was developed by using different electrodes for the electrochemical characterization and detection of EDX. The optimized voltammetric technique showed anodic signals of EDX at +1.09 V and +1.08 V on GCE and BDDE, respectively, in BR (pH 5.0) solution. The developed voltammetric method provided a very good analytical working range for EDX in BR (pH 5.0) solution on GCE and BDDE, covering concentration ranges from 1.84 μM to 12.88 μM and from 3.68 μM to 14.72 μM, respectively. The limits of detection for EDX on GCE and BDDE under these experimental conditions were calculated as 0.24 μM and 0.57 μM, respectively. The developed voltammetric methods on both electrodes were successfully applied to urine and tablet samples. Additionally, the obtained voltammetric results were compared with UV–Vis spectroscopy results.en_US
dc.identifier.citationKılıç, A., Aslan, M. ve Levent, A. (2024). Investigation of the electrochemical properties of edoxaban using glassy carbon and boron-doped diamond electrodes and development of an eco-friendly and cost effective voltammetric method for its determination. Analytical Biochemistry, 685, 1-7.en_US
dc.identifier.doi10.1016/j.ab.2023.115386
dc.identifier.endpage7en_US
dc.identifier.issn0003-2697
dc.identifier.pmid37977214
dc.identifier.scopus2-s2.0-85177165963
dc.identifier.scopusqualityQ2
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0003269723003512?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/13194
dc.identifier.volume685en_US
dc.identifier.wosWOS:001118486600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAslan, Mehmet
dc.language.isoenen_US
dc.publisherAcademic Press Inc.en_US
dc.relation.ispartofAnalytical Biochemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnticoagulanten_US
dc.subjectBoron-doped diamonden_US
dc.subjectEdoxabanen_US
dc.subjectGlassy carbonen_US
dc.subjectVoltammetryen_US
dc.titleInvestigation of the electrochemical properties of edoxaban using glassy carbon and boron-doped diamond electrodes and development of an eco-friendly and cost effective voltammetric method for its determinationen_US
dc.titleInvestigation of the electrochemical properties of edoxaban using glassy carbon and boron-doped diamond electrodes and development of an eco-friendly and cost effective voltammetric method for its determination
dc.typeArticleen_US

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