Development and validation of a novel LC-MS/MS method for the quantitation of 19 fingerprint phytochemicals in salvia species: A chemometric approach

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dc.authorid0000-0002-4090-7227en_US
dc.authorid0000-0002-2193-8386en_US
dc.authorid0000-0002-0988-9462en_US
dc.authorid0000-0001-9225-7425en_US
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorErtaş, Abdulselam
dc.contributor.authorYener, İsmail
dc.contributor.authorÖlmez, Özge Tokul
dc.contributor.authorFırat, Mehmet
dc.contributor.authorTemel, Hamdi
dc.date.accessioned2023-04-03T11:13:28Z
dc.date.available2023-04-03T11:13:28Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesien_US
dc.description.abstractBeing traditionally utilized mainly as appetizers and herbal teas as well as used to ease abdominal pains, colds and gastrointestinal issues, the genus Salvia L. has gained significant consideration owing to its remarkable phytochemicals and industrial importance. The present study aimed to develop and validate an LC-MS/MS method for the qualitative and quantitative investigation of 19 fingerprint phytochemicals in six endemic Salvia species. The validation parameters of the developed LC-MS/MS method were repeatability (intermediate precision), recovery (accuracy), limits of detection and quantification, linearity and uncertainty (U% at 95% confidence level (k = 2)). Reversed-phase HPLC separation and mass spectrometry parameters were optimized for each analyte. Ethanol extracts of the studied Salvia species collected in three consecutive years were screened for their fingerprint phytochemicals by using the developed and validated LC-MS/MS method. Moreover, studied Salvia species were subjected to multivariate analysis such as principal component analysis techniques to demonstrate the variabilities in phytochemical contents by years and parts of the samples. Roots, flowers, leaves, branches and whole plant of the Salvia species collected in 2015, 2016 and 2017 were used for the analyses. It was observed that the roots and branches of Salvia species were similar in terms of their salvianolic acid A, caffeic acid, and 6,7-dehydroroyleanone components. Accordingly, apigenin, rosmarinic acid, luteolin 7-O-glucoside, caffeic acid, salvianolic acid B, and 6,7-dehydroroyleanone were notable phytochemicals that were present in the studied Salvia species.en_US
dc.identifier.citationYılmaz, M.A., Ertaş, A., Yener, İ., Ölmez, Ö.T., Fırat, M., Temel, H. ve diğerleri. (2022). Development and validation of a novel LC-MS/MS method for the quantitation of 19 fingerprint phytochemicals in salvia species: A chemometric approach. Journal of Chromatographic Science, 60(8), 770-785.en_US
dc.identifier.doi10.1093/chromsci/bmab125
dc.identifier.endpage785en_US
dc.identifier.issn0021-9665
dc.identifier.issn1945-239X
dc.identifier.issue8en_US
dc.identifier.pmid34725681
dc.identifier.scopus2-s2.0-85139278552
dc.identifier.scopusqualityQ3
dc.identifier.startpage770en_US
dc.identifier.urihttps://academic.oup.com/chromsci/article/60/8/770/6415317?login=true
dc.identifier.urihttps://hdl.handle.net/11468/11593
dc.identifier.volume60en_US
dc.identifier.wosWOS:000789333800001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.institutionauthorErtaş, Abdulselam
dc.institutionauthorYener, İsmail
dc.institutionauthorTemel, Hamdi
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofJournal of Chromatographic Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPerformance liquid-chromatographyen_US
dc.subjectAntioxidant activityen_US
dc.subjectQuantificationen_US
dc.subjectTissuesen_US
dc.subjectProfileen_US
dc.subjectTurkeyen_US
dc.subjectAciden_US
dc.titleDevelopment and validation of a novel LC-MS/MS method for the quantitation of 19 fingerprint phytochemicals in salvia species: A chemometric approachen_US
dc.titleDevelopment and validation of a novel LC-MS/MS method for the quantitation of 19 fingerprint phytochemicals in salvia species: A chemometric approach
dc.typeArticleen_US

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