The protective effects of dexmedetomidine on the liver and remote organs against hepatic ischemia reperfusion injury in rats

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dc.contributor.authorTufek, Adnan
dc.contributor.authorTokgoz, Orhan
dc.contributor.authorAliosmanoglu, Ibrahim
dc.contributor.authorAlabalik, Ulas
dc.contributor.authorEvliyaoglu, Osman
dc.contributor.authorCiftci, Taner
dc.contributor.authorGuzel, Abdulmenap
dc.date.accessioned2024-04-24T16:14:55Z
dc.date.available2024-04-24T16:14:55Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: To investigate the protective effects of dexmedetomidine against hepatic ischemia/reperfusion (IR) injury and hepatic IR induced remote organ injury. Methods: Forty Wistar albino rats were divided into the following four groups: sham, dexmedetomidine, IR, and IR + dexmedetomidine. Hepatic ischemia was created by the Pringle maneuver for 30 min followed by a 30 min reperfusion period in the IR and IR + dexmedetomidine groups. The dexmedetomidine and IR + dexmedetomidine groups were administered dexmedetomidine (100 mg/kg, single dose) intraperitoneally after the anesthesia insult. Blood samples and hepatic, renal, and lung tissue specimens were obtained to measure serum and tissue total oxidative activity (TOA), total antioxidant capacity (TAC), paraoxonase (PON-1), and oxidative stress index (OSI) after 60 min in all groups. Results: According to the biochemical analyses of the samples taken from the serum and the liver, lung, and kidney tissues, when comparing the sham group and the IR group, TOA and OSI values were higher in the IR group, while TAC and PON-1 values were lower (p < 0.05). It was observed that TOA and OSI values were significantly lower, while TAC and PON-1 values increased with dexmedetomidine treatment (p < 0.05). In addition, dexmedetomidine ameliorated hepatic histopathological changes inducing IR, but there were no significant histopathological changes in the remote organs. Conclusion: This study demonstrated that dexmedetomidine markedly reduced the oxidative stress in serum, liver, and remote organs induced by hepatic IR injury, and ameliorated the histopathological damage in the liver. (C) 2012 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijsu.2012.12.003
dc.identifier.endpage100en_US
dc.identifier.issn1743-9191
dc.identifier.issn1743-9159
dc.identifier.issue1en_US
dc.identifier.pmid23261946
dc.identifier.scopus2-s2.0-84872615115
dc.identifier.scopusqualityQ1
dc.identifier.startpage96en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijsu.2012.12.003
dc.identifier.urihttps://hdl.handle.net/11468/15521
dc.identifier.volume11en_US
dc.identifier.wosWOS:000316936600021
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofInternational Journal of Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDexmedetomidineen_US
dc.subjectHepatic Ischemia Reperfusion Injuryen_US
dc.subjectRaten_US
dc.titleThe protective effects of dexmedetomidine on the liver and remote organs against hepatic ischemia reperfusion injury in ratsen_US
dc.titleThe protective effects of dexmedetomidine on the liver and remote organs against hepatic ischemia reperfusion injury in rats
dc.typeArticleen_US

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