Not only type 2 diabetes but also prediabetes is associated with portal inflammation and fibrosis in patients with non-alcoholic fatty liver disease

Basit Öğe Kaydı
dc.contributor.authorYilmaz, Yusuf
dc.contributor.authorSenates, Ebubekir
dc.contributor.authorYesil, Atakan
dc.contributor.authorErgelen, Rabia
dc.contributor.authorColak, Yasar
dc.date.accessioned2024-04-24T16:15:03Z
dc.date.available2024-04-24T16:15:03Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractAims: Growing evidence suggests that not only type 2 diabetes (T2D) but also prediabetes (PD) is common in patients with non-alcoholic fatty liver disease (NAFLD). However, few data exist on how PD impacts the histological characteristics of NAFLD patients. In this exploratory study, we sought to investigate the associations of PD and T2D with the severity of the histological features in patients with NAFLD. Methods: The population consisted of 280 patients with biopsy-proven NAFLD. The associations of PD and T2D with the severity of histological features of NAFLD were analyzed using multiple logistic (or ordinal logistic) regression models after adjustment for confounding factors. Results: PD and T2D was noted in 102 (36.4%) and 92 (32.8%) of patients, respectively. Of the 92 patients with T2D, ten (10.9%) were diagnosed de novo after the OGTT. PD and T2D were significantly associated with more severe portal inflammation (P < 0.01); the adjusted odds ratios (ORs) of PD and T2D for having a higher grade of portal inflammation were 1.8 [95% CI, 1.1, 3.2] and 2.6 [95% CI, 1.3, 5.8]), respectively. A similar relationship was observed for liver fibrosis (P < 0.001); specifically, the adjusted ORs of PD and T2D for having a higher grade of hepatic fibrosis were 2.4[95% CI, 1.3, 3.7] and 3.8 [95% CI, 1.9, 6.1]), respectively. Conclusion: Not only T2D but also PD is independently associated with portal inflammation and fibrosis in NAFLD patients. PD may be useful as a clinical indicator of patients who are likely to have already more severe histological findings. (C) 2014 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipInstitute of Gastroenterology, Marmara University, Istanbul, Turkeyen_US
dc.description.sponsorshipThis study was supported by the Institute of Gastroenterology, Marmara University, Istanbul, Turkey.en_US
dc.identifier.doi10.1016/j.jdiacomp.2014.01.013
dc.identifier.endpage331en_US
dc.identifier.issn1056-8727
dc.identifier.issn1873-460X
dc.identifier.issue3en_US
dc.identifier.pmid24602757
dc.identifier.scopus2-s2.0-84899551868
dc.identifier.scopusqualityQ2
dc.identifier.startpage328en_US
dc.identifier.urihttps://doi.org/10.1016/j.jdiacomp.2014.01.013
dc.identifier.urihttps://hdl.handle.net/11468/15620
dc.identifier.volume28en_US
dc.identifier.wosWOS:000335717800015
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal of Diabetes and Its Complications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPrediabetesen_US
dc.subjectNon-Alcoholic Fatty Liver Diseaseen_US
dc.subjectFibrosisen_US
dc.subjectClinical Studyen_US
dc.titleNot only type 2 diabetes but also prediabetes is associated with portal inflammation and fibrosis in patients with non-alcoholic fatty liver diseaseen_US
dc.titleNot only type 2 diabetes but also prediabetes is associated with portal inflammation and fibrosis in patients with non-alcoholic fatty liver disease
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu