Drug Interaction Between Tacrolimus and Ertapenem in Renal Transplantation Recipients

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dc.contributor.authorBora, F.
dc.contributor.authorAliosmanoglu, I.
dc.contributor.authorKocak, H.
dc.contributor.authorDinckan, A.
dc.contributor.authorUslu, H. B.
dc.contributor.authorGunseren, F.
dc.contributor.authorSuleymanlar, G.
dc.date.accessioned2024-04-24T16:18:31Z
dc.date.available2024-04-24T16:18:31Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractTo show drug interactions between tacrolimus and ertapenem, we retrospectively evaluated 13 renal transplant recipients who had been treated with ertapenem for urinary tract infections during prescription of a constant dose. The mean dose of tacrolimus to achieve desired therapeutic concentrations decreased significantly after beginning ertapenem. The decrease from 0.079 mg/kg to 0.043 mg/kg occurred 2 days after initiation of ertapenem (P < .005). These results suggest that ertapenem, which is not metabolized through the cytochrome (CYP) P450 3A metabolic pathway, interacts with tacrolimus by an unknown mechanism. This report recommends tacrolimus concentration monitoring and dose reductions when the two drugs are administered in combination.en_US
dc.identifier.doi10.1016/j.transproceed.2012.08.003
dc.identifier.endpage3032en_US
dc.identifier.issn0041-1345
dc.identifier.issue10en_US
dc.identifier.pmid23195020
dc.identifier.scopus2-s2.0-84870184023
dc.identifier.scopusqualityQ3
dc.identifier.startpage3029en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2012.08.003
dc.identifier.urihttps://hdl.handle.net/11468/16149
dc.identifier.volume44en_US
dc.identifier.wosWOS:000312042400028
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedings
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleDrug Interaction Between Tacrolimus and Ertapenem in Renal Transplantation Recipientsen_US
dc.titleDrug Interaction Between Tacrolimus and Ertapenem in Renal Transplantation Recipients
dc.typeArticleen_US

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