Effect of Intraperitoneal Curcumin Instillation on Postoperative Peritoneal Adhesions

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dc.contributor.authorTurkoglu, Ahmet
dc.contributor.authorGul, Mesut
dc.contributor.authorYuksel, Hatice Kurt
dc.contributor.authorAlabalik, Ulas
dc.contributor.authorUlger, Burak Veli
dc.contributor.authorUslukaya, Omer
dc.contributor.authorAvci, Yahya
dc.date.accessioned2024-04-24T17:14:29Z
dc.date.available2024-04-24T17:14:29Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to determine the effect of curcumin on adhesion formation in a rat cecum abrasion model. Materials and Methods: Thirty Wistar rats were randomized into three groups; the control group received saline, the curcumin group received 10 mg/kg of curcumin after cecal abrasion, and in the sham group the abdominal wall was closed without any abrasion to the cecum. On day 15, adhesions were assessed blindly using a standardized scale, and histopathological samples were taken and examined. Results: There were no incisional hernias or wound dehiscences in any animals of the three groups. A comparison of adhesion scores showed a significant difference between the curcumin (median = 1) and the control group (median = 2; p < 0.05). The grade of inflammation of the curcumin (median = 1) and the sham (median = 0) group was significantly lower than that of the control group (median = 3; p < 0.01 and p < 0.001, respectively). Hydroxyproline levels were significantly lower in the sham (48.3 +/- 11.8 mu g/mg) and the curcumin (63.8 +/- 13.9 mu g/mg) group compared to the control group (85.7 +/- 22.1 mu g/mg; p < 0.05). Conclusion: These data suggest that curcumin, administered intraperitoneally, was effective in the prevention of peritoneal adhesion formation. (C) 2014 S. Karger AG, Baselen_US
dc.description.sponsorshipDicle University Scientific Research Projects (DUBAP)en_US
dc.description.sponsorshipWe are grateful to Dicle University Scientific Research Projects (DUBAP) for their sponsorship of the English editing of this manuscript and to the experienced staff of the Health Research Center (DUSAM) Laboratory of Dicle University, Veterinary Doctor Ferhat Demir and Mehmet Tahir Mujde, for their efforts in the care of the animals and experiments.en_US
dc.identifier.doi10.1159/000369020
dc.identifier.endpage158en_US
dc.identifier.issn1011-7571
dc.identifier.issn1423-0151
dc.identifier.issue2en_US
dc.identifier.pmid25504140
dc.identifier.scopus2-s2.0-84923553776
dc.identifier.scopusqualityQ1
dc.identifier.startpage153en_US
dc.identifier.urihttps://doi.org/10.1159/000369020
dc.identifier.urihttps://hdl.handle.net/11468/17983
dc.identifier.volume24en_US
dc.identifier.wosWOS:000349694300008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofMedical Principles and Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCurcuminen_US
dc.subjectIntraperitoneal Adhesionen_US
dc.subjectAdhesion Formationen_US
dc.titleEffect of Intraperitoneal Curcumin Instillation on Postoperative Peritoneal Adhesionsen_US
dc.titleEffect of Intraperitoneal Curcumin Instillation on Postoperative Peritoneal Adhesions
dc.typeArticleen_US

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