Comparison of patients with malignant or benign laryngeal lesions and healthy indivduals in terms of haematological inflammatory parameters

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dc.authorid0000-0002-4528-5594en_US
dc.contributor.authorSizer, Bilal
dc.contributor.authorYılmaz, Ümit
dc.contributor.authorKınış, Vefa
dc.date.accessioned2022-08-15T12:25:16Z
dc.date.available2022-08-15T12:25:16Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kulak Burun ve Boğaz Hastalıkları Ana Bilim Dalıen_US
dc.descriptionWOS:000643426500001
dc.descriptionPMID: 33871141
dc.description.abstractBackground The aim of this study is to compare neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) values, which are inflammatory parameters, in precancerous and cancerous lesions and to determine whether there is a parameter that can be used in the early diagnosis of laryngeal squamous cell carcinoma. Methods In this retrospective study, 174 patients who were benign as a result of pathology, 122 patients who were malignant, 39 patients who were premalignant (335 patients in total) and 117 normal individuals were included. Data groups were divided into 4 groups as benign laryngeal lesion(BLL), precancerous laryngeal lesion (PLL), malignant laryngeal Lesion (MLL) and control group (CG). In addition, the PLL group was subdivided into mild dysplasia (MiD), Moderate Dysplasia (MoD) and severe dysplasia-carcinoma in situ (SeD/CIS). NLR, PLR and other parameters were calculated. Results NLR and PLR values were significantly different between the groups. (P = .000, P = .002) The mean NLR was higher in the MLL and PLL groups, and was lower in the BLL and control groups. The mean PLR was also higher in the MLL and PLL groups. When the groups were compared in pairs, there was a significant difference between BLL and MLL (P = .001) and MLL and CG (P = .006). The PLL group was subdivided into MiD, MoD and SeD/CIS. There was a significant difference in NLR when CG and other subgroups were compared (P = .027). Significant differences were found between CG and SeD when the groups were compared in pairs (P = .007). There was no significant difference between the groups in terms of PLR and dysplasia (P = .516). Conclusion As revealed in this study, these rates were low in the CG and BLL groups and high in the MLL group, so they could be used as markers to differentiate malignant lesions.en_US
dc.identifier.citationSizer, B., Yılmaz, Ü. ve Kınış, V. (2021). Comparison of patients with malignant or benign laryngeal lesions and healthy indivduals in terms of haematological inflammatory parameters. International Journal of Clinical Practice, 75(7), 1-5.en_US
dc.identifier.doi10.1111/ijcp.14236
dc.identifier.endpage5en_US
dc.identifier.issn1368-5031
dc.identifier.issn1742-1241
dc.identifier.issue7en_US
dc.identifier.pmid33871141
dc.identifier.scopus2-s2.0-85104849904
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1111/ijcp.14236
dc.identifier.urihttps://hdl.handle.net/11468/10176
dc.identifier.volume75en_US
dc.identifier.wosWOS:000643426500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKınış, Vefa
dc.language.isoenen_US
dc.publisherWiley-Hindawien_US
dc.relation.ispartofInternational Journal of Clinical Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.titleComparison of patients with malignant or benign laryngeal lesions and healthy indivduals in terms of haematological inflammatory parametersen_US
dc.titleComparison of patients with malignant or benign laryngeal lesions and healthy indivduals in terms of haematological inflammatory parameters
dc.typeArticleen_US

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