Can dynamic and static pupillary responses be used as an indicator of autonomic dysfunction in patients with obstructive sleep apnea syndrome?

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dc.authorid0000-0001-5742-1293en_US
dc.authorid0000-0002-3591-721Xen_US
dc.authorid0000-0001-8856-0528en_US
dc.authorid0000-0003-3346-3290en_US
dc.authorid0000-0003-2348-4856en_US
dc.contributor.authorErdem, Seyfettin
dc.contributor.authorYılmaz, Süreyya
dc.contributor.authorKarahan, Mine
dc.contributor.authorDursun, Mehmet Emin
dc.contributor.authorAva, Sedat
dc.contributor.authorAlakuş, Mehmet Fuat
dc.contributor.authorKeklikçi, Uğur
dc.date.accessioned2022-06-16T11:58:44Z
dc.date.available2022-06-16T11:58:44Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalıen_US
dc.descriptionWOS:000632380600003
dc.descriptionPMID: 33763793
dc.description.abstractPurpose We aimed to reveal whether static and dynamic pupillary responses can be used for the detection of autonomic nervous system (ANS) dysfunction in patients with obstructive sleep apnea syndrome (OSAS). Methods We included in this study patients with OSAS, who were divided into three groups according to the apnea-hypopnea index (AHI) (group 1, mild [n = 20]; group 2, moderate [n = 20]; and group 3, severe [n = 20]), and healthy controls (group 4, n = 20). Pupillary responses were measured using a pupillometry system. Results Static (mesopic PD, P = 0.0019; low photopic PD, P = 0.001) and dynamic pupil responses (resting diameter, P = 0.004; amplitude of pupil contraction, P < 0.001; duration of pupil contraction, P = 0.022; velocity of pupil contraction, P = 0.001; and velocity of pupil dilation, P = 0.012) were affected in patients with different OSAS severities. Also, AHI was negatively correlated with mesopic PD (P = 0.008), low photopic PD (P = 0.003), resting diameter (P = 0.001), amplitude of pupil contraction (P < 0.001), duration of pupil contraction (P = 0.011), velocity of pupil contraction (P < 0.001), and velocity of pupil dilation (P = 0.001). Conclusion We detected pupil responses innervated by the ANS were affected in the OSAS patients. This effect was more significant in the severe OSAS patients. Therefore, the pupillometry system can be an easily applicable, noninvasive method to detect ANS dysfunction in the OSA patients.en_US
dc.identifier.citationErdem, S., Yılmaz, S., Karahan, M., Dursun, M.E., Ava, S., Alakuş, M.F. ve diğerleri. (2021). Can dynamic and static pupillary responses be used as an indicator of autonomic dysfunction in patients with obstructive sleep apnea syndrome? International Ophthalmology, 41(7), 2555-2563.en_US
dc.identifier.doi10.1007/s10792-021-01814-0
dc.identifier.endpage2563en_US
dc.identifier.issn0165-5701
dc.identifier.issn1573-2630
dc.identifier.issue7en_US
dc.identifier.pmid33763793
dc.identifier.scopus2-s2.0-85103350283
dc.identifier.scopusqualityQ2
dc.identifier.startpage2555en_US
dc.identifier.urihttps://link.springer.com/content/pdf/10.1007/s10792-021-01814-0.pdf
dc.identifier.urihttps://hdl.handle.net/11468/10005
dc.identifier.volume41en_US
dc.identifier.wosWOS:000632380600003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErdem, Seyfettin
dc.institutionauthorYılmaz, Süreyya
dc.institutionauthorKarahan, Mine
dc.institutionauthorDursun, Mehmet Emin
dc.institutionauthorAva, Sedat
dc.institutionauthorKeklikçi, Uğur
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPupillometryen_US
dc.subjectObstructive sleep apnea syndromeen_US
dc.subjectAutonomic dysfunctionen_US
dc.subjectDiabetic autonomic neuropathyen_US
dc.titleCan dynamic and static pupillary responses be used as an indicator of autonomic dysfunction in patients with obstructive sleep apnea syndrome?en_US
dc.titleCan dynamic and static pupillary responses be used as an indicator of autonomic dysfunction in patients with obstructive sleep apnea syndrome?
dc.typeArticleen_US

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